Fatigue; Muscle, Heart, Immunosuppression
Conditions
Brief summary
Overloading is a key training principle used by athletes and coaches to improve physical performance. Intensified training periods are therefore commonly incorporated into the course of a regular training season. From a clinical point of view, very intense periods of training are associated with a temporary immunological deficiency which can lead to teh overreaching syndroms. During periods of overreaching, nutritional strategies are mainly aimed at ensuring sufficient amounts of energy to support the increase in effort. However less is known about nutritional supplements to attenuated the inflammatory/immunological response to training stress. Probiotic bacteria are defined as live food ingredients beneficial to the host's health. Numerous health benefits have been attributed to probiotics, including effects on gastrointestinal tract function and disease, immune function, hyperlipidemia, hypertension, and allergic conditions. Studies in the literature on the ergogenic effect of probiotics in athletes are still scarce today. this study aims to explore the potential role of probiotics on performance, recovery from fatigue and immune function during intensive period of training.
Interventions
DIETARY_SUPPLEMENTprobiotics
participants will be given probiotics twice a day for 15 days
DIETARY_SUPPLEMENTplacebo
participants will be given a placebo twice a day for 15 days
Sponsors
University of Padova
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* age 25-55 years * Body mass index:\> 18 and \<30 kg / m2 * Stable body weight for at least 3 months * regular practice of physical activity for at least 2 years
Exclusion criteria
* Chronic diseases (cardiovascular, hepatic, respiratory, cancer) * Acute inflammatory states, infections or other pathologies * Regular use of probiotics * Use or treatment with steroids (within the previous 3 months)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| lymphocyte subpopulation total T (CD3+) | Change from baseline to up to 15 days | lymphocyte subpopulation: total T (CD3+) % |
| T-helper (CD4+) | Change from baseline to up to 15 days | lymphocyte subpopulation: T-helper (CD4+) % |
| T-suppressor (CD8+) | Change from baseline to up to 15 days | lymphocyte subpopulation: T-suppressor (CD8+) % |
Contacts
Primary ContactTatiana Moro, PhD
Outcome results
None listed