Sleep
Conditions
Brief summary
The purpose of this study is to systematically examine the impact of different intensities of daytime light and the subsequent impact that such exposure has on non-image forming responses to light in the evening.
Interventions
BEHAVIORALLight
10 hours of light exposure during the daytime, starting 2 hours after habitual wake time
Sponsors
Palo Alto Veterans Institute for Research
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Aged 18-65 2. Good health 3. Male or female 4. Normal color vision
Exclusion criteria
1. Sleep disorders 2. Extreme chronotypes 3. Routine smoker 4. Significant hearing loss 5. Depressed 6. Alcohol use disorder 7. Use of illegal drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Suppression of melatonin production | 4 hours | Difference in salivary melatonin concentrations between active arm and 3 lux control condition |
| Phase shift in the timing of melatonin onset | 2 days | Change in the onset of melatonin secretion after experimental stimulus |
Countries
United States
Contacts
Primary ContactJamie Zeitzer, PhD
Outcome results
None listed