Differentiated Thyroid Cancer
Conditions
Keywords
differentiated thyroid cancer, pulmonary metastases, bone metastases, thyrotropin, thyroid stimulating hormone, 124I PET/CT
Brief summary
Distant metastases is the leading cause of differentiated thyroid cancer-related death. Radioactive iodine (RAI) treatment is the most effective therapy for RAI-avid metastatic differentiated thyroid cancer (DTC). It is well known that the efficacy of RAI therapy is depend on the sodium-iodide symporter protein, which can be synthesized by elevated thyrotropin stimulation. Therefore, thyrotropin stimulation before RAI treatment to ensure sufficient uptake of RAI has been a long-established procedure. According to some observational studies, thyrotropin of 25-30 μIU/mL has been adopted as the standard care protocol. However, whether thyrotropin of 25-30 μIU/mL is enough to stimulate iodine uptake in metastatic lesions remains unknown. In this study, the investigators aim to address the effect of thyrotropin on iodine uptake in metastatic DTC during levothyroxine withdrawal by two times 124I PET/CT scans on different endogenous thyrotropin levels.
Detailed description
It is estimated that 10 patients who met the study criteria will be enrolled. All patients underwent twice 124I PET/CT scans in Beijing Cancer Hospital. The first 124I PET/CT was prepared with endogenous thyrotropin 30±10 μIU/mL, the second 124I PET/CT was prepared with endogenous thyrotropin \>100 μIU/mL. The RAI-avidity of the metastases was assessed twice along with the levothyroxine withdrawal by 124I PET/CT scans.
Interventions
DIAGNOSTIC_TEST124I PET/CT
The first 124I PET/CT was prepared with endogenous thyrotropin 30±10 μIU/mL, and the second 124I PET/CT was prepared with endogenous thyrotropin \>100 μIU/mL. The RAI-avidity of the metastases was assessed twice along with the levothyroxine withdrawal by 124I PET/CT scans.
Sponsors
Peking University Cancer Hospital & Institute
Peking Union Medical College Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients underwent total thyroidectomy. 2. Patients were diagnosed with differentiated thyroid cancer by postoperative pathological examination. 3. Distant metastases confirmed by CT etc.
Exclusion criteria
1. Pregnancy or lactation. 2. Significant hepatic or renal dysfunction; 3. Unable to lie flat, still or tolerate a PET scan.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of thyrotropin level on iodine uptake in metastatic DTC lesions on twice 124I PET/CT. | 1 month | SUV metrics of RAI-avid metastatic DTC lesions on twice 124I PET/CT. |
Countries
China
Contacts
Primary ContactYansong Lin, Prof
Backup ContactZhi Yang, Prof
Outcome results
None listed