Iron and Vitamin Supplementation in Hip/Knee Surgery

Emacrit Plus in Prosthetic Hip and Knee Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04880499

Enrollment

Registered

2021-05-10

Start date

2021-04-21

Completion date

2022-07-08

Last updated

2023-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anemia, Hip Arthropathy, Iron Poor Blood, Knee Arthropathy, Orthopedic Disorder

Brief summary

Randomized controlled trial to evaluate the efficacy of oral iron supplementation plus cofactors in reducing the prevalence of preoperative anemia in a cohort of 60 patients undergoing elective prosthetic hip or knee surgery.

Interventions

DIETARY_SUPPLEMENTIron plus folic acid, vitamin B2, B6, B12, C, and E

A number of 30 subjects are supplemented with iron plus folic acid, vitamin B2, B6, B12, C, and E daily for 60+/-15 days before orthopedic surgery.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Males and females * ASA 1, 2, or 3 * No neuropsychiatric conditions * Acceptance of informed consent * Elective prosthetic hip or knee surgery

Exclusion criteria

* ASA 4 * Present or past neuropsychiatric conditions * Hip or knee revision surgery * Use of iron as dietary supplement * Known erythrocytosis * Incompatible hypersensitivities * Iron metabolism disorders * Lymphoproliferative disorders

Design outcomes

Primary

Measure	Time frame	Description
Change of blood hemoglobin levels	Baseline and 60 days +/- 15 days	Change of hemoglobin concentration (g/dl) from baseline and after 60 days +/- 15 days

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026