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Diagnostic Performance of Arterial Time for CT Assessment of Parietal Enhancement Defect for the Diagnosis of Ischemia in Mechanical Small Bowel Occlusions: a Comparative Study With Portal Time

Diagnostic Performance of Arterial Time for CT Assessment of Parietal Enhancement Defect for the Diagnosis of Ischemia in Mechanical Small Bowel Occlusions: a Comparative Study With Portal Time

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04880421
Acronym
PORTOGRELE
Enrollment
158
Registered
2021-05-10
Start date
2021-04-27
Completion date
2023-04-26
Last updated
2023-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bowel Obstruction Small

Brief summary

Intestinal obstruction is a frequent cause of emergency room visits and represents about 4-7% of the causes of acute abdominal pain syndrome and up to 30% in adults over 60 years old. Although 65 to 80% of patients are treated medically, small bowel obstruction remains a serious pathology, with a high mortality rate that can reach 25% in case of small bowel ischemia. It is necessary to systematically perform a CT scan in the initial workup of small bowel obstructions to confirm the diagnosis, identify the mechanism and detect signs of ischemia that would require emergency surgery. The best sign for the diagnosis of ischemia is the defect or asymmetry of parietal enhancement of the dilated small bowel. In the literature, this sign is described almost exclusively at portal time. In case of suspicion of mesenteric ischemia (another serious pathology affecting the small bowel), it is recommended to perform an examination with three acquisitions (without injection, arterial time, and portal time). The department's experience has shown that arterial time is sometimes more sensitive than portal time for visualizing a parietal enhancement defect of the small bowel in mechanical occlusions. Very few studies have investigated the diagnostic performance of parietal enhancement asymmetry on arterial time in mechanical occlusions of the small bowel.

Interventions

None listed

Sponsors

Fondation Hôpital Saint-Joseph
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum

Inclusion criteria

* Patient whose age is ≥ 18 years * Patient with a diagnosis of mechanical small bowel obstruction on CT performed between April 2014 and December 2019 * Patient who had a CT scan with at least 3 phases: injection-free, arterial time, portal time * French-speaking patient

Exclusion criteria

* Patient who did not have surgery within the first 24 hours * Patient with a history of abdomino-pelvic surgery in the month preceding the scan * Patient under guardianship or curatorship * Patient deprived of liberty * Patient under court protection * Patient who objects to the use of his or her data for this research

Design outcomes

Primary

MeasureTime frameDescription
Diagnostic performance of arterial versus portal phase in CT for the evaluation of parietal enhancement defectYear 1This ouctome corresponds to the evaluation of the sensitivity, specificity, positive predictive value and negative predictive value of the acquisition for parietal enhancement defect as a sign of ischemia.

Secondary

MeasureTime frameDescription
Inter-observer reproducibility of parietal enhancement defect analysis at arterial timeYear 1This outcome corresponds to the evaluation of the Kappa coefficient of inter-observer reproducibility.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026