Neuropsychological Indicators of SCD Progression

In Individuals With Subjective Cognitive Decline, Age, Memory and Action Speed Scores at Baseline Predict Progression to Cognitive Impairment

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04880252

Acronym

SCD-CI

Enrollment

Registered

2021-05-10

Start date

2019-05-01

Completion date

2020-05-01

Last updated

2021-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Biomarkers, Cognitive Assessment, Cognitive Decline, Neurocognitive Disorders, Neurodegenerative Diseases, Subjective Cognitive Decline

Keywords

Biomarkers, Cognitive assessment, Cognitive decline, Neurocognitive disorders, Neurodegenerative diseases, Neuropsychological assessment, Risk of progression, Subjective cognitive decline

Brief summary

Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. The investigators objective was to examine baseline neuropsychological indicators that could discriminate between people in whom the SCD progressed to a mild or major NCD and people in whom the SCD remained stable. The investigators retrospectively included patients consulting for SCD at a university medical center's memory center (Amiens, France) and who had undergone three or more neuropsychological assessments at least 6 months apart. The relationship between domain-specific scores and the global cognitive score (GCS, as a function of final status (stable SCD vs. progression toward a mild or major NCD)) was examined using a generalized linear mixed model.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients who had been referred to the memory center at Amiens University Medical Center (Amiens, France). * patients who had undergone three neuropsychological assessments at least 6 months apart, from 2005 * patients who met the criteria for SCD.

Exclusion criteria

* patients who didn't meet the criteria for SCD

Design outcomes

Primary

Measure	Time frame	Description
Variation of neuropsychological indicators (global congnitive score) between NCD et SCD patients	one year	subjective cognitive decline (SCD) neurocognitive disorders (NCD) neuropsychological indicators could discriminate between people in whom SCD progressed to a mild or major NCD and people in whom SCD remained stable. A global cognitive score was created using all 5 tests : Alice Heim 4-I tests inductive reasoning ; Short-term verbal memory was assessed with a 20-word free-recall test; Two measures of verbal fluency were used: phonemic and semantic; Vocabulary was assessed using the Mill Hill Vocabulary test.

Countries

France

Outcome results