Carcinomatosis, Peritoneal
Conditions
Brief summary
Pressurised intraperitoneal aerosol chemotherapy is a new surgical technique, developed for the treatment of initially unresectable peritoneal carcinomatosis. The objective of this study was to compare the results of PIPAC associated with systemic chemotherapy with those of systemic chemotherapy alone in patients with gastric peritoneal carcinomatosis without metastasis other than peritoneal, and WHO performance status \<3.
Interventions
DRUGPIPAC with systemic chemotherapy
PIPAC procedures were performed every 6 to 8 weeks, alternating with systemic chemotherapy, replacing a cycle of intravenous chemotherapy.
DRUGSystemic chemotherapy alone
Intravenous chemotherapy
Sponsors
Association Francaise de Chirurgie
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients 18 years or over * Patients with adenocarcinoma-type gastric non-resectable péritonéale carcinomatosis. * Patients without metastasis other than peritoneal. * WHO performance status \<3 * Patients treated either with PIPAC administered in alternation with systemic chemotherapy (PIPAC\_CHEM) or by systemic chemotherapy alone (ONLY\_CHEM) * Patient informed
Exclusion criteria
\- Patients opposed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival at 6 months | 6 months | Overall survival at 6 months from diagnosis of carcinomatosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Duration of hospital stay | 6 months | duration of hospitalization up to 6 months after the diagnosis of carcinomatosis |
| overall survival from the diagnosis of carcinomatosis and from the diagnosis of the primary tumour. | 3 years | overall survival throughout the study follow-up from the diagnosis of carcinomatosis and from the diagnosis of the primary tumour. |
Countries
France
Outcome results
None listed