Effect of WB-EMS on Parkinson's Disease

Effects of Combined Whole Body Electromiostimulation (WB-EMS) and Dynamic Movements on Motor and Cognitive Performance, Neurotrophic Factors and Alpha-synuclein in Parkinson's Disease

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04878679

Enrollment

Registered

2021-05-07

Start date

2021-04-15

Completion date

2023-04-30

Last updated

2023-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Brief summary

The aim is to establish adequate and suitable protocols for PD patients and to determine the WB-EMS effects on muscle strength, balance, walking, cognitive functions,neurotrophic factors and alpha-synuclein. Thirty-six PD patients, aged from 50 to 80 years, will be recruited and randomly assigned to two experimental groups (EGs and EGc) and one control group (CG), in order to perform dynamic movements with WB-EMS. EGs will undergo to 12-20 minutes of progressive supervised WB-EMS (4 sec. 85 HZ and 4 sec. rests) combined to light dynamic movements, two-time per week for 12/24 weeks. EGe will undergo to 12-20 minutes of progressive supervised WB-EMS 7 Hz) combined with cardiovascular training with rowing machine. CG will not perform any type of physical activity. Pre and post intervention assessment will be carried out on the following areas: physical assessment, neurocognitive, neurotrophic factors and alpha-synuclein assesments. A 3 months follow-up will be performed.

Interventions

OTHERStrenght training combined with WB-EMS

Bodyweight exercise training combined with WB-EMS (2 times/week) with a 85Hz electrical impulse

OTHERCardiovascular training with WB-EMS

Cardiovascular training , using the rowing machine, combined with WB-EMS (2 times/week) with a 7Hz electrical impulse

OTHERControl group

No physical activity

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* age from 50 to 80 years old * clinical diagnosis of parkinson's disease from 1 to 3 of Hoehn and Yahr Scale * no partecipation to other physical activity program

Exclusion criteria

* MMSE values \< 24 * inability to walk 6 minutes without assistance * use of medications and other things that may affect cognitive and motor functions * presence of contraindications in the use of WB-EMS

Design outcomes

Primary

Measure	Time frame	Description
UPPER LIMB STRENGHT CHANGE	14 Weeks	HAND GRIP TEST
LOWER BODY FLEXIBILITY	14 Weeks	CHAIR SIT AND REACH TEST
BALANCE AND STABILITY TEST CHANGE	14 Weeks	TINETTI BALANCE AND GAIT EVALUATION TEST
NUMBER OF ERRORS CHANGE	14 Weeks	STROOP TEST;
NEUROTROPHIC FACTORS CHANGE	14 Weeks	BLOOD DRAW
ALPHA-SYNUCLEIN CHANGE	14 Weeks	BLOOD DRAW
REPETITIONS NUMBER CHANGE	14 Weeks	30S ARM CURL TEST
TIME(S) CHANGE	14 Weeks	SODA POP TEST ;
DISTANCE (M) CHANGE	14 Weeks	6 MINUTE WALKING TEST

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026