Skin Condition
Conditions
Brief summary
To assess Isagenix-Collagen Elixir on skin condition improvement
Interventions
DIETARY_SUPPLEMENTCollagen drink
Testing product
DIETARY_SUPPLEMENTBlank
Placebo drink
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults aged above 20 years old
Exclusion criteria
* Subject who is not willing to participate in this study. * Patients with diseases of the skin, liver, kidney. * Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * Female who is pregnant or nursing or planning to become pregnant during the course of the study. * Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks. * Constant drug use * Participated cosmetic product human study in the past 3 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of TIMP-1 of blood | Change from Baseline TIMP-1 at 4 weeks | Venous blood was sampled to measure TIMP-1 |
| The change of MMP-1 of blood | Change from Baseline MMP-1 at 4 weeks | Venous blood was sampled to measure MMP-1 |
| The change of skin elasticity | Change from Baseline skin elasticity at 4 weeks | Soft Plus was utilized to measure skin elasticity. Units: arbitrary units |
| The change of skin collagen density | Change from Baseline skin collagen density at 4 weeks | DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units |
| The change of skin texture | Change from Baseline skin texture at 4 weeks | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units |
| The change of skin wrinkles | Change from Baseline skin wrinkles at 4 weeks | VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin brown spots | Change from Baseline skin brown spots at 4 weeks | VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units |
| The change of TNF-α of blood | Change from Baseline TNF-α at 4 weeks | Venous blood was sampled to measure TNF-α |
| The change of skin melanin index | Change from Baseline skin melanin index at 4 weeks | Soft Plus was utilized to measure skin melanin index. Units: arbitrary units |
| The change of skin L* value | Change from Baseline L* value at 4 weeks | Chroma Meter MM500 was utilized to measure skin L\* value. Units: arbitrary units, 0-100 |
| The change of skin moisture | Change from Baseline skin moisture at 4 weeks | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 |
| The change of skin spots | Change from Baseline skin spots at 4 weeks | VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units |
| The change of skin UV spots | Change from Baseline skin UV spots at 4 weeks | VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units |
| The change of IL-10 of blood | Change from Baseline IL-10 at 4 weeks | Venous blood was sampled to measure IL-10 |
| The change of SOD-RBC of blood | Change from Baseline SOD-RBC at 4 weeks | Venous blood was sampled to measure SOD-RBC |
| The change of f-thiols of blood | Change from Baseline f-thiols at 4 weeks | Venous blood was sampled to measure f-thiols |
| The change of t-GSH of blood | Change from Baseline t-GSH at 4 weeks | Venous blood was sampled to measure t-GSH |
| The change of GST-RBC of blood | Change from Baseline GST-RBC at 4 weeks | Venous blood was sampled to measure GST-RBC |
| The change of MDA of blood | Change from Baseline MDA at 4 weeks | Venous blood was sampled to measure MDA |
| The change of blood total antioxidant capacity (TAC) | Change from Baseline TAC at 4 weeks | Venous blood was sampled to measure concentrations of TAC |
Other
| Measure | Time frame | Description |
|---|---|---|
| The change of total cholesterol of blood | Change from Baseline total cholesterol at 4 weeks | Venous blood was sampled to measure total cholesterol |
| The change of triglyceride of blood | Change from Baseline triglyceride at 4 weeks | Venous blood was sampled to measure triglyceride |
| The change of uric acid of blood | Change from Baseline uric acid at 4 weeks | Venous blood was sampled to measure uric acid |
| The change of creatinine of blood | Change from Baseline creatinine at 4 weeks | Venous blood was sampled to measure creatinine |
| The change of BUN of blood | Change from Baseline BUN at 4 weeks | Venous blood was sampled to measure BUN |
| The change of SGPT of blood | Change from Baseline SGPT at 4 weeks | Venous blood was sampled to measure SGPT |
| The change of SGOT of blood | Change from Baseline SGOT at 4 weeks | Venous blood was sampled to measure SGOT |
Countries
Taiwan
Outcome results
None listed