Osteoarthritis, Knee
Conditions
Keywords
Total knee replacement, Cognitive load, Gait, Proprioception, Dual task
Brief summary
Knee Osteoarthritis (OA) is one of the most common conditions causing disability and limitation in the elderly population, with 13% of women and 10% of men over the age of 60 suffering from symptomatic knee osteoarthritis. Pain and other symptoms of OA significantly affect the quality of life, manifesting itself in pain, decreased range of motion, functional limitation and change in gait patterns. Total Knee Replacement Surgery (TKR) is the most common solution for patients with advanced cartilage erosion and is considered a successful surgery with high satisfaction rates (about 80%). The surgery becomes necessary when pain limits the daily functioning and impairs the quality of life and after the failure of conservative treatment. Still, patients undergoing TKR suffer in the first period after surgery from pain, decreased balance and proprioceptive impairment. Despite the improvement in pain and function, the rates of falls after surgery do not change drastically and remain high. About a third of older adults fall each year, leading to fractures, functional decline and in some cases death. Walking is a complex task, and with advancing age walking becomes less automatic and requires additional attention. Among adults, it is known that an increased risk of falls is associated with reduced ability to perform complex walking tasks, such as walking while talking or crossing obstacles. After TKR, most falls occur while walking due to slipping / tripping. In addition, proprioceptive impairment, pain and poor balance are associated with an increased risk of falling after TKR. The mechanism underlying these effects may be increased allocation of cognitive resources to walking. Thus, this study will examine the ability of people before and after TKR to perform complex walking tasks, in order to examine the change in attention allocation to walking following surgery. It is hypothesized that after surgery, the ability to walk while performing an additional task will be lower than prior to surgery.
Interventions
BEHAVIORALGait analysis pre- and post- surgery
None (observational)
Sponsors
Emek Medical Center
University of Haifa
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Able to walk at least for 1 minute with no assistive device * Able to understand and complete simple instructions
Exclusion criteria
* Diagnosed dementia * Diseases impairing balance * Diagnosed rheumatoid arthritis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Gait speed | One month prior to surgery, 4.5 months post-surgery | Change in gait speed as measured using an instrumented mat |
| Change in gait variability | One month prior to surgery, 4.5 months post-surgery | Change in coefficient of variation of stride time and stride length, as measured using an instrumented mat |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in dynamic Balance | One month prior to surgery, 4.5 months post-surgery | Mini Balance Evaluation Systems Test (Mini-BesTest) is a functional test of dynamic balance. Scores range from 0 to 28, with better scores indicating better balance. |
| Change in balance self-efficacy | One month prior to surgery, 4.5 months post-surgery | The Activities-specific Balance Confidence (ABC) Scale is a self-reported measure of balance self-efficacy. Ranging from 0 to 100, better scores indicate better balance self-efficacy |
| Change in Joint position sense | One month prior to surgery, 4.5 months post-surgery | Estimation of knee position using the Physiological Profile Assessment (PPA). Specifically, the difference between intended knee flexion angle and achieved flexion angle is calculated in degrees (worse performance is identified via larger difference) |
| Cognitive function | One month prior to surgery | Montreal Cognitive Assessment (MoCA) is a test of cognitive function. Ranging from 0 to 30, better scores denote better cognitive function. |
| Change in movement reinvestment | One month prior to surgery, 4.5 months post-surgery | Movement reinvestment will be measured using the Movement Specific Reinvestment Scale (MSRS), a self-report measure of conscious monitoring of movement. Scores range from 10 to 60, with higher scores denoting more conscious movement monitoring |
| Change in Pain, stiffness, physical function | One month prior to surgery, 4.5 months post-surgery | The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Is a self-report questionnaire of pain, stiffness and physical function in people with knee osteoarthritis. Scores range 0-20 for pain, 0-8 for stiffness and 0-68 for physical function |
Countries
Israel
Outcome results
None listed