Dry Eye
Conditions
Brief summary
60 samples are take to determine the effects of topical insulin on tear inflammatory mediators interleukin 1a, interleukin 6 and matrix metalloprotenase 9 in diabetics with dry eye disease.
Detailed description
Tear samples are taken to compare the levels of inflammatory markers (IL 1a, IL6 and MMP 9) pre-and post treatment with topical insulin in normal saline compared to standard therapy and normal saline in diabetics with dry eyes and also to correlate the IL 1a, IL6 and MMP 9 levels with clinical outcomes in diabetics with dry eyes treated with topical insulin in normal saline, standard therapy and normal saline
Interventions
DRUGTopical Insulin
Insulin (Actrapid) diluted in Normal Saline is given to participant 1 drop to both eyes 4 times per days for 4 weeks
Sponsors
Universiti Kebangsaan Malaysia Medical Centre
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* all diabetics aged 18 - 50 years of age with at least mild OSDI scores
Exclusion criteria
* Diabetics on contact lenses * Diabetic with history of ocular surgery in the preceding 3 months * Post menopausal women * Known mild dry eye with prior usage of topical therapy who are unable to discontinue * Known case of allergic eye disease * Sjogren's syndrome patients * Unwilling or unable to attend 6 follow up and sampling sessions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biochemical marker 1 | 4 weeks | Interleuikn 1-alpha |
| Biochemical marker 2 | 4 weeks | Interleukin 6 |
| Biochemical marker 3 | 4 weeks | Matrix metallo-proteinase 9 |
Countries
Malaysia
Contacts
Primary ContactAtikah bt Asini, M.D.
Outcome results
None listed