Postoperative Delirium
Conditions
Brief summary
The relationship between zonulin and interleukin-8 levels and postoperative delirium development in patients who had femur fracture surgery under regional anesthesia
Detailed description
Patients who are over 65 years of age and scheduled for femur fixation surgery will be included in the study. Blood samples for zonulin and interleukin-8 levels will be taken at the day prior to the surgery. All patients will be evaluated by the Turkish version of the Delirium Rating Scale-Revised-98 (DRS-R-98) for delirium development at the postoperative 1., 2. and 3. days. Patients with a DRS-R-98 score of 11 points or higher will be included in the Group Delirium. And second blood samples for zonulin and interleukin-8 levels will be taken at the time of diagnosis. Postoperative pain scores of the patients will recorded by using a numerical rating scale (NRS).
Interventions
DIAGNOSTIC_TESTEvaluation of Delirium development
Postoperative pain scores of the patients will recorded by using a numerical rating scale.
Sponsors
Dr. Gokhan Vural
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients over 65 years with mini mental state score \> 21, undergoing femur fixation surgery
Exclusion criteria
* anticholinergic drug use, known epilepsy, Parkinson, Alzheimer's disease, dementia, cognitive function disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| preoperative Zonulin | in the preoperative 24. hour | The relation between postoperative delirium development and preoperative blood zonulin levels. The correlation between them will be analyzed by statistical analysis. |
| postoperative Zonulin | At the postoperative 72. hour | The relation between postoperative delirium development and postoperative blood zonulin levels The correlation between them will be analyzed by statistical analysis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| preoperative Interleukin-8 | in the preoperative 24. hour | The relation between postoperative delirium development and preoperative blood interleukin-8 levels. The correlation between them will be analyzed by statistical analysis. |
| postoperative Interleukin-8 | At the postoperative 72. hour | The relation between postoperative delirium development and postoperative blood interleukin-8 levels. The correlation between them will be analyzed by statistical analysis. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pain | At the postoperative 0., 12., 24 hours | The relation between postoperative delirium development and postoperative pain score will be documanted. the scores are; zero; have no pain. 0-4 points: mid pain. 5-7points: mild pain. 8-10 points pain score will be named severe pain scores. and The correlation between them will be analyzed by statistical analysis. |
Countries
Turkey (Türkiye)
Outcome results
None listed