Use of Dietary Supplements in Patients at Risk of Abortion Treated With Progesterone.

Supplementation With Hyaluronic Acid, Alpha-lipoic Acid, Magnesium, and Vitamin D and B6 in Patients at Risk of Abortion Treated With Progesterone: a Pilot Study.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04874285

Enrollment

Registered

2021-05-05

Start date

2021-05-03

Completion date

2023-05-11

Last updated

2023-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy, High Risk

Brief summary

The trial aims to investigate the effect of supplementation with hyaluronic acid, alpha-lipoic acid, magnesium, vitamin D and vitamin B6 in progesterone-treated pregnant women with risk factors for abortion.

Interventions

DIETARY_SUPPLEMENTHA

hyaluronic acid, alpha-lipoic acid, vitamin D and vitamin B6

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Women with risk factor for abortion (sub-chorionic hematoma during gestation or ART procedures)

Exclusion criteria

* Other pregnancy-related conditions * Diabetes or hypertension * Concomitant pharmacological therapies (anticoagulant or antihypertensive) * Use of tocolytic drugs two months prior to enrollment * Association with hypoglycemic drugs

Design outcomes

Primary

Measure	Time frame	Description
reduction of the abortion rate	1 day (single time-point before week 20 of gestation)	rate of abortion

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026