Memory, Delayed
Conditions
Brief summary
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Interventions
DEVICEDeep Brain Stimulation
Deep brain stimulation will be used
BEHAVIORALMemory and spatial navigation tasks
Tasks may include walking around the room, on a treadmill, or in a controlled environment using VR (virtual reality) or AR (augmented reality) technology designed to simulate real-world navigation. Participants may also use Meta Ray-Ban glasses to capture new memories while recording neural activity.
BEHAVIORALPhysiological Signals
Physiological signals such as heart rate, respiration, and skin conductance will be monitored while completing lab tasks. Motion capture and eye-tracking may also be used.
BEHAVIORALQuestionnaires and Assessments
Participants complete questionnaires and assessments to assess subjective emotional experience.
Sponsors
Duke University
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute of Mental Health (NIMH)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* 12 years of age or older and has undergone RNS system placement * Willing to provide informed consent and participate the study * Ability to read and write English fluently
Exclusion criteria
* Unwilling to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spatial memory | Throughout study completion, an average of 2-4 days per year | Spatial memory will be measured using virtual, augmented and real-world spatial navigation tasks where participants will be asked to navigate a previously learned rout as well as if they recognize objects (i.e. landmarks) that appeared along the route (photos of seen landmarks vs unseen landmarks). |
| Memory performance change | Throughout study completion, an average of 2-4 days per year | Memory performance will be measured using excess path length, latency, and accuracy rate. |
| Oscillatory activity change | Throughout study completion, an average of 2-4 days per year | Changes in theta, gamma, and theta-gamma coupling will be measured both in relation to changes in memory performance on trials with and without deep brain stimulation as well as in relation to body, head, and eye position in a virtual, augmented, or real-world environment. |
Countries
United States
Contacts
CONTACTGabriela Vilchez
CONTACTNanthia Suthana, PhD
PRINCIPAL_INVESTIGATORNanthia Suthana, PhD
University of California, Los Angeles
Outcome results
None listed