Renal Cell Carcinoma
Conditions
Keywords
Renal Cell Carcinoma, Survivin, Immnuohistochemistry
Brief summary
detection of Survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.
Detailed description
renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system. deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell survival, facilitating accumulations of multiple mutations and augment resistance to immune-surveillance. Survivin is a member of inhibitor of Apoptosis Protein family (IAPs). it play a role in cell cycle regulation by inhibiting apiptosis. Survivin is over-expressed in many human neoplasms.
Interventions
DIAGNOSTIC_TESTsectioning and staining of renal neoplasms after nephrectomy operation
nephrectomy operations will be done to patients diagnosed as having renel tumors
Sponsors
Sohag University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients suffer from renal cell carcinomas
Exclusion criteria
* patients received pre-operative chemotherapy or radiotherapy. patients with insufficient clinical data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| expression of survivin in neoplastic and adjacent normal renal tissues | april, 2021 | Survivin is highly expressed in neoplastic renal tissues compared to normal ones by immunohistochemical measures.. |
Countries
Egypt
Outcome results
None listed