Inflammatory Response, Muscle Soreness, Old Age; Atrophy
Conditions
Brief summary
Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity. Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle to combine high muscle strength production with low energy cost. ECC contractions are significantly more damaging to the muscles and produce greater muscle strength, for these reasons there is a greater risk of inducing muscle damage before the muscle is able to adapt. Parmigiano Reggiano (PR) has some peculiar bromatological characteristics. The proteins contained in it, and in particular the potentially bioactive peptide sequences, can rapidly provide the amino acids necessary to promote muscle growth and repair during exercise. Furthermore, PR can be an important source of fatty acids, of which a significant amount of short-chain fatty acids (SCFA) which are known to have important clinical effects on body composition and metabolic health and can have a systemic anti-inflammatory effect. Therefore, the central hypothes is that PR consumed during RET can provide more energy substrates and improve muscle recovery. To date, no studies have studied its function on recovery from exercise nor in the elderly.
Interventions
DIETARY_SUPPLEMENTParmigiano Reggiano
subjects will receive 50 g/die of the dietary supplement 10 days before performing the eccentric exercise session
DIETARY_SUPPLEMENTWhey Protein
subjects will receive 20 g/die of the dietary supplement 10 days before performing the eccentric exercise session
Sponsors
University of Padova
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* age \>60 years old or \>18 and \< 30 years old * BMI \>18 and \<30 kg/m2 * stable body weight in the past 3 months * valid medical certifacate for practice of physical activity
Exclusion criteria
* diabetes or pre-diabetes as for ADA guidelines * chronic diseases (cardiovascular, liver, respiratory, cancer, etc) * acute inflammatory status * regular practice of intense physical activity (\>2 sessions/week) * treatment with steroids in the past 3 months * regular use of \>50g/die of Parmigiano Reggiano
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| maximum volountary contraction (MVC) | Change from baseline to up to 5 days | maximal muscle volountary contraction mesured in Newton |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| reactive Proteinc C | Change from baseline to up to 5 days | plasmatic levels of reactive Proteinc C (mg/dL) as a markers of muscle damage |
| Creatin Kinase | Change from baseline to up to 5 days | plasmatic levels of Creatin Kinase (mmol/dL) as a markers of muscle damage |
| IL-6 | Change from baseline to up to 5 days | plasmatic levels of IL-6 (mg/dL) as a markers of muscle damage |
| delayed onset muscle soreness (DOMS) | Change from baseline to up to 5 days | level of delayed onset muscle soreness (DOMS) masured via Visual Analogue Scale (VAS) scale where 0 is the minimal value (no pain) and 10 is the maximum value (maximum pain). |
Countries
Italy
Contacts
Primary ContactTatiana Moro, PhD
Backup ContactAntonip Paoli, MD
Outcome results
None listed