Effectiveness of Holmium and Thulium Lasers With Ureteroscopy for Urinary Lithiasis

Ureteroscopy for Upper Tract Lithiasis : Comparison of Costs and Effectiveness of Both Holmium and Thulium Lasers, in a Prospective Monocentric Study.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04871984

Acronym

LiThuHol

Enrollment

200

Registered

2021-05-04

Start date

2021-05-31

Completion date

2022-10-31

Last updated

2021-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Stone, Ureteral Stone

Brief summary

Holmium laser is the current gold standard for lithotripsy on urinary lithiasis, while Thulium is brand new. The latter has been released in July 2020 in Europe, and only in-vitro studies have been published. The aim of this study is to compare the stone free rate in ureteroscopy, for all consecutive patients treated with laser fragmentation, between both Holmium and Thulium lasers. The costs and complications will also be studied.

Interventions

DEVICEUreteroscopy for upper tract stone treatment with Holmium laser

Rigid or flexible ureteroscopy for ureteral or renal stone. Lithotripsy with Holmium laser

DEVICEUreteroscopy for upper tract stone treatment with Thulium laser

Rigid or flexible ureteroscopy for ureteral or renal stone. Lithotripsy with Thulium laser

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* renal ou ureteral stone confirmed by an abdominal and pelvic computed tomography * treatment with rigid or flexible ureteroscopy * laser lithotripsy during the procedure * bacteriological examination of urine (sterile, bacterial colonization or treated by antibiotics)

Exclusion criteria

* non-use of laser for stone lithotripsy * pregnant women * under 18 years old * refusal to give informed consent * urinary malformation

Design outcomes

Primary

Measure	Time frame	Description
Stone free rate	Three months after surgery	Urinary tract echography or renal computer tomography imaging. Patients with residual fragments under 4 mm are stone free.

Secondary

Measure	Time frame	Description
Perioperative complications	During the intervention	Recording data about ureteric perforation and bleeding
Operating time	Immediately after the intervention	All surgeries are included
Postoperative complications	Up to three months after surgery	Recording data according to the Clavien classification (rates of hospitalisation, pain, infection and surgical revision)

Contacts

Primary ContactPierre BIGOT, MD-PhD

PiBigot@chu-angers.fr0241355830

Backup ContactBertrand DELBARRE, Resident

Bertrand.Delbarre@chu-angers.fr0241353518

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026