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Structural Cartography of the Insula in Temporal Epilepsy Patients

Structural Cartography of the Insula in Temporal Epilepsy Patients

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04871555
Acronym
CON-INSULA
Enrollment
115
Registered
2021-05-04
Start date
2021-06-01
Completion date
2022-12-31
Last updated
2021-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy, Temporal Lobe, MRI Scans

Keywords

structural connectivity, insula, temporal lobe epilepsy

Brief summary

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Detailed description

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Interventions

OTHERMRI

structural imaging

Sponsors

Centre de Recherche du Centre Hospitalier de l'Université de Montréal
CollaboratorOTHER
University Hospital, Lille
CollaboratorOTHER
Hospices Civils de Lyon
CollaboratorOTHER
Central Hospital, Nancy, France
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* epileptic patients: temporal epilepsy or temporal plus epilepsy (temporomesial epilepsy, basal temporal epilepsy, mesio lateral or lateral epilepsy, temporo insular epilepsy, operculo insular epilepsy) * patients who underwent video EEG monitoring with recorded seizures (at least one) * patients who underwent a brain MRI with DTI sequence before epilepsy surgery * patients who did not refuse the use of their clinical and MRI data for this study

Exclusion criteria

* patients younger than 15 years old * patients with previous brain surgery (before MRI) * uncompleted MRI sequences (DTI, T1 anatomical)

Design outcomes

Primary

MeasureTime frameDescription
cartography of insula in temporal epilepsy patients1 year after the last inclusionCompared with healthy group, definition of different patterns of insular structural connectivity in epileptic patients

Secondary

MeasureTime frameDescription
Correlation structural cartography and electroclinical data1 year after the last inclusioncorrelation between patterns of insular structural connectivity and subtypes of epilepsy defined by electroclinical data

Countries

France

Contacts

Primary ContactLouise Tyvaert, Pr
l.tyvaert@chru-nancy.fr33383857723

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026