Skip to content

Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use

Addressing Mental Health Comorbidities: Integrated CBT to Improve Functioning in Veterans With Co-Occurring Anxiety and Substance Use

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04871100
Enrollment
40
Registered
2021-05-04
Start date
2023-03-01
Completion date
2026-10-01
Last updated
2026-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety Disorder, Hazardous Drinking, Posttraumatic Stress Disorder

Keywords

Veterans, Anxiety, Stress Disorders, Post-Traumatic, Alcohol Drinking, Psychosocial functioning

Brief summary

Individual with anxiety and post-traumatic stress disorder often use alcohol in ways that could cause them harm. Treating both mental health concerns and alcohol use at the same time can help reduce difficulties engaging in multiple treatments. The investigators are evaluating how a cognitive behavioral therapy program that helps Veterans with anxiety, posttraumatic stress disorder, and alcohol use at the same time can help improve the participants lives.

Detailed description

Co-occurring hazardous drinking, anxiety disorders, and PTSD are problematic combinations of mental health concerns experienced by deployed Veterans. Veterans who have been deployed are at particular risk for experiencing problems in functioning and reintegration related to mental health disorders and hazardous drinking. Co-occurring anxiety and hazardous drinking heavily impact psychosocial functioning and quality of life. Although cognitive behavior therapy (CBT) can promote psychological recovery through improvements in functioning and quality of life, most CBT protocols do not address co-occurring disorders, leading to inefficient and disjointed treatment. The current research seeks to adapt and test the Unified Protocol (UP) for deployed Veterans with hazardous drinking. The use of combined CBT for both anxiety disorders and hazardous drinking has the potential to more efficiently and effectively improve functioning, reduce symptoms, and promote psychosocial recovery.

Interventions

BEHAVIORALUnified Protocol- Alcohol

Transdiagnostic cognitive behavior therapy for emotional disorders modified to include CBT for alcohol use.

BEHAVIORALUsual care

referrals to VA care for SUD and anxiety

Sponsors

VA Office of Research and Development
Lead SponsorFED

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Participants will be randomized to receive the intervention or a control intervention.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* meeting diagnostic criteria for current anxiety disorder and * endorsing hazardous alcohol use

Exclusion criteria

-need for acute medically-supervised detoxification with exclusionary criteria of * high-risk suicidality * psychotic symptoms, or * cognitive impairment that could interfere with engagement in weekly psychotherapy

Design outcomes

Primary

MeasureTime frameDescription
Social Adjustment Scale- Self Report2-weeksEvaluates individuals' satisfaction with social situation. Greater scores reflect greater social/occupational impairment (range 42-210).
Beck Anxiety Inventorypast 30 daysEvaluates levels of anxiety in past month. Higher scores reflect greater anxiety (range 0-63).
Addiction Severity Index30 daysAssessment of substance use and related problems. Higher scores in each domain indicate problems related to substance use in that domain (range for each domain 0-1).

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORAnthony Ecker, PhD

Michael E. DeBakey VA Medical Center, Houston, TX

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 19, 2026