Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04869852

Enrollment

Registered

2021-05-03

Start date

2021-05-30

Completion date

2023-06-30

Last updated

2021-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Photoaging

Keywords

Wrinkles, Polyphenols, Vitamins

Brief summary

Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins. Mango extract has been reported to protect against photo-aging of the skin in an animal model exposed to UVB radiation, reducing the length of wrinkles and increasing collagen bundles. Beta-carotene and other carotenoids are known to provide skin protection from sunlight, but other compounds in mangos, may also be important in reducing oxidative damage in aging skin. We have recently completed a pilot study showing a clear trend in skin wrinkle reduction when postmenopausal women consumed 85g of Ataulfo mangos, four times per week for 16 weeks. To confirm and extend these results, a larger study is proposed.

Interventions

OTHERFood

85g mango, 4x/week

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Healthy postmenopausal women aged 50 - 70, Fitzpatrick skin type I, II, or III

Eligibility

Sex/Gender

FEMALE

Age

50 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* 50 - 70 years old * Postmenopausal * Fitzpatrick skin type I, II, or III * BMI 18.5 - 35 * Must be willing to comply with all protocol requirements * Must be willing to have flash photo facial images taken with the imaging systems

Exclusion criteria

* Smokers * Allergy to mangos * Vegans/vegetarians * Adults unable to consent

Design outcomes

Primary

Measure	Time frame	Description
Wrinkles	week 20	Wrinkle score measured by Facial Image Analysis System

Secondary

Measure	Time frame	Description
Facial Hydration	week 20	Moisture measured by MoistureMeterSC
Facial Redness	week 20	Redness measured by Facial Image Analysis System
Facial Elasticity	week 20	measured by Cutometer
Gut microbiome	week 20	analyze for changes in gut microbiome diversity measures (Shannon Diversity)

Contacts

Primary ContactRaja Sivamani, MD, MS, AP

raja.sivamani@integrativeskinresearch.com9165241216

Backup ContactVivien Fam, PhD, RDN

vivien@integrativeskinresearch.com5307605968

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026