The Ontario Multi-Regional Hospital COVID-19 Registry (COREG)- Recovery Trajectory Sub-study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04868864

Acronym

COREG

Enrollment

200

Registered

2021-05-03

Start date

2021-05-15

Completion date

2022-12-31

Last updated

2021-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 Pneumonia, Sars-CoV-2 Infection

Brief summary

Radiological and lung function recovery following Covid-19 infection.

Detailed description

The investigators propose to conduct pulmonary LDCT imaging and physiological lung function assessments, and combine this with detailed multi-regional hospitalization clinical data collection on COVID-19 cases (COREG registry); to inform long-term pulmonary and extra-pulmonary consequences and the recovery trajectory following COVID-19 infection.

Interventions

DIAGNOSTIC_TESTCT scan

Non-enhanced LDCT scans of the thorax will be taken using standard technology on helical CT system

DIAGNOSTIC_TESTPulmonary Function Test

Standard pulmonary function testing will be conducted by trained pulmonary technologists following the American Thoracic Society standards

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients discharged from hospital post COVID-19 infection who have radiographic and clinical evidence of COVID-19 pneumonia during hospitalization. * Patients with evidence of unresolved radiographic changes or persistent hypoxemia.

Exclusion criteria

* Failure to comply with study procedures.

Design outcomes

Primary

Measure	Time frame	Description
Pulmonary changes on LDCT Scan	Through study completion, an average of 9 months	Identify pulmonary changes utilizing LDCT chest to characterize the pulmonary recovery trajectory of survivors of COVID-19.

Secondary

Measure	Time frame	Description
DLCO	Through study completion, an average of 9 months	Identify DLCO changes over time to characterize the pulmonary recovery trajectory of survivors of COVID-19.
TLC	Through study completion, an average of 9 months	Identify TLC changes over time to characterize the pulmonary recovery trajectory of survivors of COVID-19.
FEV1	Through study completion, an average of 9 months	Identify FEV1 changes over time to characterize the pulmonary recovery trajectory of survivors of COVID-19.
FVC	Through study completion, an average of 9 months	Identify FVC changes over time to characterize the pulmonary recovery trajectory of survivors of COVID-19.

Countries

Canada

Contacts

Primary ContactMylinh Duong, MD

duongmy@mcmaster.ca905 525-9140

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026