The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

The Effect of Perioperative Lidocaine Intravenous Infusion on Neutrophil Extracellular Trapping After Surgery for Stomach Cancer

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04868747

Enrollment

Registered

2021-05-03

Start date

2021-04-01

Completion date

2021-04-02

Last updated

2023-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric Cancer

Brief summary

To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping after minimally invasive surgery for stomach cancer

Detailed description

To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping, especially citrullinated histone3, neutrophil elastase, myeloperoxidase

Interventions

DRUGLidocaine

The participants receive perioperative lidocaine infusion with general anesthesia for gastrectomy.

DRUGnormal saline

The participants receive perioperative normal slaine infusion with general anesthesia for gastrectomy.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* diagnosis of stomach cancer * ASA class I-III * no metastatic disease

Exclusion criteria

* hepatic, renal disease * chronic inflammatory disease, eg. rheumatoid arthritis * steroid or anti-inflammatory drug medication * allergies to study drugs * neuropsychiatric disease * refusal of participation * breast feeding or pregnancy * weight \< 40 kg

Design outcomes

Primary

Measure	Time frame	Description
serum concentration of NET(neutrophil extracellular trapping)-related biomarker	24 hours after surgery	NET-related biomarker (citrullinated histone3, neutrophil elastase, myeloperoxidase)

Secondary

Measure	Time frame	Description
quality of recovery	24 hours after surgery	The quality of recovery is assessed using questionnaire. This questionnaire includes 15 items. The score range is from 0 to 150. The higher score means the better quality of recovery after surgery.
postoperative pain	24 hours after surgery	The postoperative pain is assessed using numeric rating scale (NRS; 0=no pain, 10=the maximal pain)
survival of patients	5 years	The survival of patients is assessed using electronic medical record.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026