SCREENING OF CELIAC DISEASE IN SCHOLAR CHILDREN IN ITALY

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04867863

Enrollment

4570

Registered

2021-04-30

Start date

2015-05-31

Completion date

2018-06-30

Last updated

2021-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Celiac Disease, Dental Caries

Keywords

celiac disease, children, caries, HLA DQ2, HLA DQ8, screening

Brief summary

The main aim of the study is to currently define the prevalence of celiac disease (CD) in children aged 5-10 years in 2 Italian cities (Ancona and Verona). The screening protocol is based on a 1st line genetic test (searche of HLA DQ2/DQ8 genotypes) followed by a serological diagnosis (IgA TTG and IgG DGP).

Detailed description

All scholar children aged 5-10 years living in the cities of Ancona and Verona will be invited to partecipate. Children enrolled will be investigated as follows: 1. HLA DQ2/DQ8 genotyping (by a rapid test) 2. In children genetically predisposed to CD serological investigations will be performed (both IgA TTG and IgG DGP antibodies) 3. The overall population will be evaluated for the prevalence and severity of dental caries (by using the DMFT/dmft index)

Interventions

None listed

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to 10 Years

Healthy volunteers

Inclusion criteria

age 5-10 -

Exclusion criteria

celiac disease, on a gluten free diet \-

Design outcomes

Primary

Measure	Time frame
prevalence of celiac serology in children aged 5-10	2 years

Secondary

Measure	Time frame
prevalence of dental caries in children genetically predisposed to CD in comparison with children not predisposed	2 years

Countries

Italy

Outcome results