Chronic Pain, Chronic Pancreatitis, Depression, Quality of Life
Conditions
Brief summary
Chronic pancreatitis (CP) is associated with recurrent intractable abdominal pain, pancreatic exocrine insufficiency and endocrine dysfunction. Very few studies had evaluated the quality of life in CP, and even a fewer have assessed the mental status in these patients. In the current study, we proposed to evaluate the the relationship between pain, quality of life and depression status in two large independent cohorts of patients with CP. We also proposed to evaluate the brain metabolites in the right and left anterior cingulate cortex, basal ganglia, hippocampus and prefrontal cortex using magnetic resonance spectroscopy. We further proposed to evaluate the pasta metabolites and look for associations with the mental state. Finally, we proposed to evaluate how CP related education of the patients could impact on their mental status and response to interventions on pain.
Interventions
OTHERPatient education about chronic pancreatitis.
Patients in the second cohort were educated about their disease phenotype in a structured and personalised manner that included their disease course, symptoms, imaging, treatment option and possible long-term outcomes and prognosis. This was followed by answering all the queries of the patient and their caregivers. The patients were advised to visit the Pancreas clinic after 3-months for re-evaluation of the clinical, psychological and metabolic parameters.
Sponsors
Asian Institute of Gastroenterology, India
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
A. Inclusion Criteria: * Age 18-60yrs * Both genders * Documented CP for at least 3 years * Capable and willing to provide informed consent B.
Exclusion criteria
* Acute exacerbation of pancreatitis * Pancreatic malignancy * On anti-depressant and antipsychotic medications * Concomitant psychiatric illness (other than depression) * Pancreatic malignancy * Major co-morbidities * Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in depression scores | 3 months | Measured by the BDI II score |
| Improvement in Quality of life parameters | 3 months | Measured by the EORTC-QLQc30 + PAN28 |
| Change in brain metabolite profiles | 3 months | Measured by using Magnetic resonance spectroscopy |
Countries
India
Outcome results
None listed