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Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections

Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections - A Retrospective Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04865003
Enrollment
289
Registered
2021-04-29
Start date
2014-01-01
Completion date
2020-12-31
Last updated
2021-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection, Inflammation, Mediastinitis, Neck Abscess

Brief summary

Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections.

Detailed description

Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections. The study enrolled patients admitted to the Emergency Center of Vojvodina with the diagnosis of multispace DNI with or without DNM either as the primary diagnosis or with discharged diagnosis after surgical treatment during 7-years period. The data were obtained from patient medical records.

Interventions

OTHERtreatment of infection

Sponsors

Clinical Center of Vojvodina
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* patients admitted to the hospital due to deep neck infection affecting two or more spaces with or without descending necrotizing medioastinitis * complete diagnosis and treatment data available from medical charts

Exclusion criteria

* incomplete medical data * infection confined to one deep neck space * patients treated under local anesthesia * patients with superficial skin infections * iatrogenic infections * infected tumors

Design outcomes

Primary

MeasureTime frameDescription
Incidence of mediastinitisWithin 6 hours of admissionNeck and chest computed tomography (CT)

Secondary

MeasureTime frameDescription
Microbiological findings in DNI and DNMWithin 1 week of admissionPrevalence of microorganisms in mediastinitis
Average number of hospital daysThrough study completion, an average of one monthComparison of average number of hospital days in DNI and DNM
Incidence of complicationsWithin 30 days from admissionComplications among DNI and DNI+DNM groups
Number of infected deep neck spacesWithin 6 hours of admissionNeck and chest computed tomography (CT)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026