Dyspnea and Idiopathic Pulmonary Fibrosis

Dyspnea in Idiopathic Pulmonary Fibrosis (IPF): Multidimensional Assessment and Correlations With Lung Function

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04864990

Acronym

DYS-PID

Enrollment

Registered

2021-04-29

Start date

2021-10-22

Completion date

2025-04-07

Last updated

2026-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Fibrosis

Brief summary

Longitudinal prospective exploratory study on the evolution of dyspnea, in its sensory and affective dimensions, in patients followed for idiopathic pulmonary fibrosis (IPF), between inclusion and a 6-month evaluation

Detailed description

Dyspnea is a multidimensional experience involving a sensory component and an affective component. To better understand this symptom in IPF, this study will describe the different component of dyspnea and their evolution between inclusion and a 6-month evaluation in IPF patients. There is no strong correlation between the intensity of dyspnea and respiratory function impairments. Innovative techniques demonstrated abnormalities in ventilation variability and pulmonary compliance in patients with interstitial lung disease. These abnormalities could be more relevant to explain dyspnea. The objective of this work is also to assess the link between the different dimensions of dyspnea and respiratory functional parameters, ventilation variability and ventilatory mechanics measured by impulse oscillometry technique.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* diagnosis of IPF according to ATS/ERS guidelines * dyspnea at rest (VAS ≥ 1) or on exertion (mMRC ≥ 1)

Exclusion criteria

* diffuse interstitial lung disease other than IPF * other significant chronic pathology that may cause dyspnea: chronic obstructive pulmonary disease, asthma, heart failure, anemia, obesity (non-exhaustive list), except for pulmonary hypertension

Design outcomes

Primary

Measure	Time frame	Description
Evolution of the sensory and affective components of dyspnea	baseline, 6 months	Description and changes in sensory (SQ) and affective (A2) scores of the Multidimensional Dyspnea Profile (MDP) questionnaire

Secondary

Measure	Time frame	Description
Evolution of dyspnea during activities of daily living	baseline, 6 months	Description and changes in San Diego Shortness of Breath Questionnaire (SOBQ) score
Association between the sensory and affective components of dyspnea and quality of life, anxiety symptoms, lung volumes, gas exchanges, ventilation variability, pulmonary compliance, pulmonary hypertension	baseline, 6 months	Correlation between SQ and A2 scores of the MDP questionnaire and King's Brief Interstitial Lung Disease (K-BILD) questionnaire score, State Trait Anxiety Inventory (STAI-Y2) score, lung volumes measured by plethysmography, DLCO, PaO2, delta of desaturation during the 6-minute walk test, coefficient of variation of the tidal volume at rest, impulse oscillometry reactance, systolic pulmonary artery pressure assessed by cardiac ultrasound
Assess the prevalence of refractory dyspnea	baseline, 6 months	Description of the prevalence of patients with visual anolog scale at rest \> 3 or mMRC scale \> 2

Countries

France

Contacts

PRINCIPAL_INVESTIGATORCécile Chenivesse, MD,PhD

University Hospital, Lille

Outcome results