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Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products

Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04864925
Enrollment
46
Registered
2021-04-29
Start date
2020-12-28
Completion date
2021-08-25
Last updated
2022-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid19

Brief summary

SARS COVID 2 has caused a pandemic of proportions unparalleled in the past 100 years. The virus has an uncanny ability for transmission and as such has been difficult to control. The spread of the virus has affected everything from education, business, politics and survival. While the investigators have learned a great deal in the last 9 months they still face an uncertain day to day existence. Health care workers are particularly vulnerable to transmission of this virus because of their close contact with patients. Moreover, dentists are particularly vulnerable because the virus is spread via aerosols which are generated quite easily in the dental office putting dentists and their associates at risk. The oral cavity appears to be a likely domain for viral carriage particularly since both taste and smell are hallmark effects of the virus. With these issues at hand it will be of great advantage to have a simple routine oral hygiene method in the effort to reduce the oral viral load. There is some reason to expect that oral hygiene procedures with known anti-microbial effects could have some use in our efforts to reduce or control the oral viral load. With this issue in mind investigators feel that stannous fluoride could modify the virus in such a manner as to effectively reduce the oral viral load.

Detailed description

Study will measure reduction of SARS-CoV-2 levels in the oral cavity after brushing for up to an hour. Subject sampling will occur at baseline, 15 min, 30 min, and 60 min

Interventions

DRUGColgate Total Clean Mint

2 minutes of whole mouth toothbrushing

DRUGTom's Botanically Bright Peppermint

2 minutes of whole mouth toothbrushing

Sponsors

Colgate Palmolive
Lead SponsorINDUSTRY

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
No

Inclusion criteria

* Enrolled subjects between the ages of 18-64 and have tested positive for Covid19.

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCRBaselinePrimary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026