Effects of Breathing Patterns on Post-prandial Vascular Function

The Effects of Different Breathing Styles on Post High-Fat Meal Blood Vessel Function

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04864184

Enrollment

Registered

2021-04-28

Start date

2020-12-01

Completion date

2021-09-30

Last updated

2021-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Breathing, Yogic breathing

Brief summary

The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.

Interventions

BEHAVIORALNormal physiologic rate breathing

2-minute breathing exercises will be completed every 15 minutes.

BEHAVIORALSlow breathing

2-minute breathing exercises will be completed every 15 minutes.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Masking description

Participants will be blinded to the respiratory rates being practiced during each study visit. Breathing patterns will be completed in random order.

Intervention model description

Each participant will complete 2 different sessions in random order.

Eligibility

Sex/Gender

MALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

• Male participants ages 18-35 years

Exclusion criteria

* Infection within the previous 4 weeks * Renal disorders * Any cardiovascular disorders such as prior myocardial infarction, known coronary artery disease, personal history of stroke, heart failure, cardiac arrhythmias * Chronic obstructive pulmonary disease * Diabetes * Inflammatory bowel disease * HIV, rheumatoid arthritis, chronic or other inflammatory conditions * Currently taking steroids or other anti-inflammatory medications * Current use of nonsteroidal anti-inflammatory drugs * Smoking * Stage 2 hypertension or higher (systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher) * Lactose intolerance

Design outcomes

Primary

Measure	Time frame	Description
Change in flow-mediated dilation	At baseline and at again 1, 2, 4 hours post high-fat meal consumption	Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation.
Changes in oxidative stress	Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption.	Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 13, 2026