Sickle Cell Disease
Conditions
Keywords
ICU Intensive Care Units, Transthoracic Echocardiography, Left Ventricular Function
Brief summary
Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non invasive technique that may allow us to observe such myocardial dysfunction. No such study has yet been conducted in patient hospitalised in intensive care unit. Our hypothesis is that strain alteration during vaso-occlusive crisis, if they do exist, can be correlated with other markers of myocardial injury such as troponin level or thoracic pain.
Interventions
OTHEREvaluation of global longitudinal strain using routinely recorded echocardiography images
There are no particular intervention performed in patients in this study, because echocardiography is part of the standard of care of patients hospitalised in the ICU for vaso occlusive crisis.
Sponsors
Bicetre Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hospitalisation in an intensive care unit for vaso-occlusive crisis
Exclusion criteria
* Pregnancy * Individuals under guardianship * Unsufficient echogenicity * Thoracic pain prohibiting echocardiography assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Global longitudinal strain | Day 0 | Measure of global longitudinal strain using speckle tracking echocardiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Troponine level | Day 0 | — |
| Electrocardiogram QT interval | Day 0 | — |
| Electrocardiogram ST elevation | Day 0 | — |
| Electrocardiogram negative T waves | Day 0 | — |
| Thoracic pain | Day 0 | Numerical rating scale from 0 to 10 assessed by the patient |
Countries
France
Contacts
Primary ContactXavier Monnet, MD, PhD
Outcome results
None listed