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Brain-Physical Optimization Conditioning

Neurocognitive Optimization and Enhancement for Brain Health and Performance

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04863469
Enrollment
66
Registered
2021-04-28
Start date
2020-10-20
Completion date
2025-10-20
Last updated
2022-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Physical Performance

Keywords

cognitive fatigue, demand, endurance performance, perceived exertion, effort

Brief summary

Brain-Physical Optimization Conditioning (B-POC) aims to enhance physical performance by expanding the traditional focus of endurance training from purely physical training to the domain of cognitive endurance (Staiano et al., 2015; Dallaway et al., 2017). The current study seeks to isolate neurocognitive mechanisms of performance, particularly under high stress (e.g., physical or cognitive load) conditions, and to develop corresponding cognitive optimization tools.

Detailed description

Brain-Physical Optimization Conditioning (B-POC) aims to enhance physical performance by expanding the traditional focus of endurance training from purely physical training to the domain of cognitive endurance (Staiano et al., 2015; Dallaway et al., 2017). B-POC uses an acute mentally fatiguing task during routine exercise with the aim of optimizing the effects of physical endurance (e.g., aerobic exercise). B-POC differs from other types of cognitive training by increasing the cognitive demands of a specific concurrent task rather than teaching a cognitive strategy and relying on task transfer effects. Similar to strengthening a muscle, cognitive trainings may be one means of increasing Soldier's cognitive capacity and improving performance (Walton et al., 2018).

Interventions

BEHAVIORALB-POC high load intervention

aerobic exercise \[heartrate range (HRR) 70-75% of max HR, on treadmill\] and a computerized high-load task for 45 minutes, 3 times per week, for 6 weeks

BEHAVIORALB-POC low load intervention

aerobic exercise \[heartrate range (HRR) 70-75% of max HR, on treadmill\] and a computerized low-load task for 45 minutes, 3 times per week, for 6 weeks

Sponsors

Walter Reed Army Institute of Research (WRAIR)
Lead SponsorFED

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy active duty Soldiers * 18-40 years old * Available for study duration

Exclusion criteria

* Failure of an Army Physical Fitness/Combat Test (APFT/ACFT) test * On a physical profile that prevents them from 1) engaging in intense aerobic exercise, 2) running on a treadmill, 3) riding the stationary bike, and 4) performing a cognitive task on a computer screen. * Medically non-deployable * Impaired cognitive function due to medication, injury or illness, * Have been advised by a medical professional not to engage in aerobic exercise * Are a pregnant female

Design outcomes

Primary

MeasureTime frameDescription
Time to Failure Test7 weeksThe Time to Failure Test (TFT) requires participants to run on a treadmill with increases in either grade (0.5% increase) and speed (\ 0.3-0.5 mph) every two minutes in an alternating format for the first 16 minutes, after which settings remain constant until self termination of the exercise. The TFT settings (work rate) are calculated from an individual's last 2 mile run time. Physiological load (heart rate, oxygen consumption) and perceived exertion (RPE) are measured throughout the TFT. The primary outcome is change in time to failure (minutes, seconds) on the endurance test from baseline to post0test (\ 7 weeks).

Secondary

MeasureTime frameDescription
Dynamic MarksmanshipPre-to-post ruck time (~30-90 minutes)The Dynamic Marksmanship Test requires participants to complete four increasingly difficult phases of target identification (friend vs. foe) and elimination using a rifle marksmanship simulator (EST). The test is completed both before and after a 3-mile ruck march, which is completed with +30% bodyweight. Physiological output (HR), and subjective ratings of workload (NASA-TLX) are assessed throughout each marksmanship test. The primary outcome is change in accuracy (%) from pre-ruck performance to post-ruck performance.

Countries

United States

Contacts

Primary ContactBrad Fawver, PhD
bradley.j.fawver.civ@mail.mil253-968-4878

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026