Lung Cancer, Lung Function Decreased, Radiation Pneumonitis
Conditions
Brief summary
This is a prospective observational study aiming: 1) To quantify lung function using perfusion dual energy computed tomography (DECT) and use this information at the time of treatment planning with preferential sparing of functional lung parenchymal 2) to validate results of lung function obtained using DECT with lung perfusion scintigraphy results, the current standard method; 4) to compare dosimetry of whole lungs vs. functional lungs in patients treated with either stereotactic body radiotherapy (SBRT) for early stage lung cancer or conventional radiotherapy for locally advanced lung cancer and 5) to evaluate lung function 6, 12 and 24 months post-radiotherapy with both perfusion DECT and pulmonary function tests and compare radiation dose-map to functional lung-map.
Interventions
RADIATIONThoracic radiotherapy
Patients will have pre-treatment and post-treatment perfusion DECT for baseline and post-treatment lung function
Sponsors
Varian Medical Systems
Centre hospitalier de l'Université de Montréal (CHUM)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥ 18 years * ECOG 0-2 * Pulmonary neoplasia, confirmed histopathologically or by imaging * Prognosis evaluated ≥ 1 year by attending MD * Clinically acceptable lung capacity to undergo radiotherapy * Initial assessment including history, physical examination, biochemistry, PFT, chest radiograph, chest and abdominal-pelvic scan, PET * Written consent * The patient must be available for treatment and monitoring. Patients registered in the study should be treated in our center.
Exclusion criteria
* Previous radiotherapy in the radiation field * Presence of any major medical condition that, in the opinion of the investigator, would prevent follow-up at 6, 12 and 24 months post-radiotherapy. * Iodine allergy * Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lung function quantification at baseline | Baseline | To quantify lung function using perfusion DECT and use this information at the time of treatment planning with preferential sparing of functional lung parenchyma. |
| Radiation-induced lung function damage quantification | at 12 months after radiotherapy | To evaluate lung function post-radiotherapy with both perfusion DECT and pulmonary function tests and compare radiation dose-map to functional lung-map. |
Countries
Canada
Outcome results
None listed