Epilepsy
Conditions
Brief summary
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
Detailed description
The goal of this proposed research is to record the effects of ketamine on brain activity to understand the changes that occur during dissociation in epilepsy patients with stereoEEG.
Interventions
DRUGKetamine
Study participants will receive 0.5mg/kg of ketamine - one single infusion
Sponsors
Stanford University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient in Stanford Epilepsy Monitoring Unit * Age \>18 years old.
Exclusion criteria
* Lifetime psychotic or bipolar disorder * Inability to speak, read or understand English * Pregnant or nursing females * Prior adverse ketamine response
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with dissociative events during ketamine infusion as assessed by CADSS (Clinician-Administered Dissociative State Scale) | up to 1 week | The CADSS is an instrument for the measurement of dissociative symptoms. The CADSS comprises 23 subjective items and participant's responses are coded on a 5-point scale (0 = Not at all; 4 = Extreme). The higher the number on the CADSS, the more severe the symptoms. |
Countries
United States
Contacts
CONTACTArjay Cordero
PRINCIPAL_INVESTIGATORKarl Deisseroth, MD, PhD
Stanford University
Outcome results
None listed