AV Node Isolation in Atrial Fibrillation vs. Modulation by Pace and Ablate Strategy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04859933

Enrollment

Registered

2021-04-26

Start date

2020-10-01

Completion date

2022-02-28

Last updated

2022-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, AV Node Ablation, Escape; Rhythm

Brief summary

AV-node ablation (AVNA) is a common therapy option for rate control strategy of permanent atrial fibrillation with numerous side effects. The investigators hypothesised that an isolation of the AV node is concomitant with less occurrence of new bundle brunch blocks, more frequent preservation and higher rate of escape rhythm compared to AVNA. This retrospective study includes 20 patients being treated with AV-node isolation (AVNI) and 40 historical AVNA-controls. Among others these two methods were compared regarding escape rhythm, delta QRS, procedure time, ablation points, fluoroscopy time and total dose area product (DAP).

Interventions

PROCEDUREAV-node isolation

Abaltion performed in the right atrium isolating the AV-node from the atrium

PROCEDUREAV-node ablation

Right sided ablation of the AV-node

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* paroxysmal, persistend or permanent atrial fibrillation; indication for AVNA

Exclusion criteria

* other indications for AVNA than atrial fibrillation as AVNRT, atrial flutter, atrial tachycardia

Design outcomes

Primary

Measure	Time frame
AV-node escape rhythm	intraoperative, follow-up after 1 to 3 month
bundle branch blocks	intraoperative, follow-up after 1 to 3 month

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026