Cardiopulmonary Disease, Covid19, Dyspnea, Epigenetic Disorder, Lung Function Decreased
Conditions
Keywords
Cardiopulmonary Exercise Testing, Lung Function Testing, Echocardiography, DNA-methylation, Covid19
Brief summary
The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated. This study will recruit subjects with a clinical diagnosis of Post-Covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. Patients' symptoms will be correlated to physiological measures and compared to predicted values. In addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or DNA-methylation patterns. In addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.
Detailed description
The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated. For example, the extent to which subjective symptoms correlate with physiological impairments are not known. This study will recruit subjects with a clinical diagnosis of Post-Covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. Patients' symptoms will be correlated to physiological measures and compared to predicted values. In addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or DNA-methylation patterns. In addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.
Interventions
DIAGNOSTIC_TESTPhysiological testing
Cardiopulmonary exercise testing, Lung Function Testing and in some cases echocardiography. 20 subjects will perform DNA-methylation testing.
Sponsors
Linkoeping University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Confirmed or clinically highly suspected Covid19-infection * Symptom duration at least 12 weeks following first occurence of symptoms * No other disease that better could explain the symptoms than Covid19
Exclusion criteria
* Age \<18 years * Unability to perform a maximal exercise test * Unability to understand written or spoken Swedish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peak Oxygen Consumption (VO2peak) | At baseline | Cross-sectional evaluation of VO2peak and the association with symptoms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| VE/VCO2-slope | At baseline, in subset at 1 year | Cross-sectional evaluation of VE/VCO2 and the association with symptoms |
| Diffusion Capacity (DLCOc) | At baseline, in subset at 1 year | Cross-sectional evaluation of DLCOc and the association with symptoms |
| Peak Oxygen Consumption (VO2peak) | In subset of subjects at 1 year | Improvement in VO2peak over 1 year |
| Forced Vital Capacity (FVC) | At baseline, in subset at 1 year | Cross-sectional evaluation of FVC and the association with symptoms |
| Total Lung Capacity (TLC) | At baseline, in subset at 1 year | Cross-sectional evaluation of TLC and the association with symptoms |
| Forced Expiratory Volume in 1 second (FEV1) | At baseline, in subset at 1 year | Cross-sectional evaluation of FEV1 and the association with symptoms |
Countries
Sweden
Outcome results
None listed