COPD, COPD-like
Conditions
Keywords
COPD, Diaphragm, Voluntary cough, Abdominal muscle activation
Brief summary
The study will recruit subject of healthy adult, COPD-like patient and patient with COPD to investigate the difference of respiratory performance. We will measure the body composition, respiratory muscle force, pulmonary function and performance of voluntary cough. The muscle thickness of abdominal muscle and diaphragm, assessment of diaphragm during different breathing pattern and the muscle activation during voluntary cough will also being determined. We hypothesized that there will be a significantly different between three group on the performance of voluntary cough, and the correlation between each variable will be further investigated.
Detailed description
The specific aims of the study are: 1. difference of respiratory muscle performance between three groups 2. the correlation between respiratory symptom and pulmonary functional test 3. difference of functional respiratory performance (peak cough flow of voluntary cough) between three groups 4. muscle activation of abdominal muscle and diaphragm during performing voluntary force 5. performance of diaphragm under different breathing load
Interventions
None listed
Sponsors
National Cheng-Kung University Hospital
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Health subject Inclusion Criteria: * aged 20 years or above * currently not being diagnosis as COPD * less than 4 times/week of aerobic exercise 2. COPD-like subject Inclusion Criteria: * aged 20 years or above * currently not being diagnosis as COPD * presented of COPD symptoms (coughing, sputum production and dyspnea), last for 3 months and more than 2 years * score more than 1 on modified Medical Research Council (mMRC) or COPD Assessment Test (CAT) 3. COPD subject Inclusion Criteria: * aged 20 years or above * currently being diagnosis as COPD * haven't participated in any pulmonary rehabilitation program in the past three months
Exclusion criteria
* Untreated comorbidities for COPD * Postural asymmetries (Scoliosis, length discrepancy of the lower limbs or other previous surgical history of spine) * Chronic nonspecific lumbopelvic pain * Gynecological or abdominal surgery in the previous year * Pregnancy or post-delivery in the previous 6 months * Neurological or inflammatory disorders * Any conditions that may interfere with the data collection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peak cough flow | baseline | Peak coughing velocity of voluntary cough in liter/second |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory muscle force | baseline | MIP/MEP in cmH2O |
| Pulmonary function test | baseline | PEF/MVV in liter/min |
| Muscle thickness during voluntary force | baseline | tRA/tEO/tIO/tTrA/tD in millimeter |
| Muscle activation during voluntary force | baseline | aURA/aLRA/aEO/aIOTrA/aD (all the data will be collected through surface EMG and will be presented as maximal voluntary contraction in %) |
| Diaphragm assessment | baseline | QB\_ex/DB\_ex/Sniff\_ex in millimeter |
Countries
Taiwan
Outcome results
None listed