Malnutrition Elderly
Conditions
Keywords
Sarcopenia, Oral nutritional supplement, elderly people, nutritional education, malnutrition risk
Brief summary
Past studies have pointed out that adequate intake of calories and protein in the elderly can deferred sarcopenia and debilitating conditions. Therefore, this study intends to use oral nutrition as a way of nutritional supplements, without affecting the subjects' normal meal intake, and supplements with snacks It is expected that there will be benefits in protein and muscle synthesis. However, the palatability of oral nutritional products will affect the effectiveness of nutritional supplements. Therefore, this test provides nutrients that are easy for the subjects to ingest with a variety of flavors, in order to achieve the test calories and protein needs. In order to investigate and compare the nutritional status, serum zinc and vitamin D status in healthy (MUST score 0) elderly and at risk of malnutrition elderly, we recruited healthy elderlies in the nursing home.
Detailed description
In this study, subjects were randomly assigned. Through a multi-center research method, a total of 100 eligible subjects were recruited, and their consent was obtained and a subject consent form was signed. The subjects were divided into two groups according to the way of nutritional intervention, including nutritional education (NE) and nutritional supplement drink (NSD), with 50 people in each group. The NE group is given regular nutrition education by qualified clinical nutritionists to ensure the effectiveness of nutrition education. In the NSD group, in addition to nutrition and health education, daily oral supplements (Meiji Mei Balance, Meiji Co., Ltd., Tokyo, Japan) are provided daily, and snacks are supplemented between lunch and dinner and before bedtime, 2 per day. bottle. The two groups were divided into groups by lottery, and the intervention period was 12 weeks. During the intervention period, blood will be drawn at the beginning, 6th, and 12th week of the case, and blood pressure, body position, body composition and muscle strength will be measured, and dietary intake will be assessed. At the same time, a quality of life survey will also be conducted. survey, QoL survey. Moreover, we recruited 50 healthy elderly to investigate and compare the nutritional status, serum zinc and vitamin D status in healthy elderly and at risk of malnutrition elderly. This group was considered as a control group and we didn't do any intervention after blood collection and physical measurements.
Interventions
At the intervention period (0th to 12th week of the experiment), In addition to nutrition and health education, subjects were provided with 2 bottles of commercially available oral nutritional supplements (Meiji Mei Balance, Meiji Co., Ltd., Tokyo, Japan) every day, between lunch and dinner and before bedtime.
At the intervention period (0th to 12th week of the experiment) , subjects will be given regular nutrition education by a qualified clinical dietitian to ensure the effectiveness of nutrition education, in order for the nutrition education group to benefit from participating in this trial, the subjects will also be provided with the same nutritional products after the trial
Sponsors
Meiji Co., Ltd.
Taipei Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
This study was a clustered, randomized, parallel, multicenter clinical trial.
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. age \>65 years old (regardless of gender) 2. Malnutrition risk judgment: Subjects were assessed as moderate and high malnutrition risk with the malnutrition risk screening tool MUST (Malnutrition Universal Screening Tool)
Exclusion criteria
1\. chronic diseases such as diabetes, end stage of chronic kidney disease, cancer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood biochemical value | at the start of the experiment and at the 6th and 12th week | blood cell analysis, liver function test (AST/ALT), blood sugar, triglycerides, nutritional indicators (serum albumin), kidney function (urea nitrogen, creatinine), vitamin D, zinc, etc |
| Blood pressure | at the start of the experiment and at the 6th and 12th week | measure systolic and diastolic blood pressure. |
| Body position measurement | at the start of the experiment and at the 6th and 12th week | height, weight, waist-to-hip ratio, body mass index, etc. |
| Body composition | at the start of the experiment and at the 6th and 12th week | Use a body fat machine to measure muscle mass, fat mass and water content. |
| Muscle strength test | at the start of the experiment and at the 6th and 12th week | measure 6m walking speed, grip strength measurement, etc. |
| Diet pattern | at the start of the experiment and at the 6th and 12th week | Evaluate the 24-hour recall method and Three-day dietary record |
| Quality of life and health status | at the start of the experiment and at the 6th and 12th week | Use the quality of life questionnaire (SF-36) to evaluate the quality of life and health status |
Countries
Taiwan
Outcome results
None listed