Infertility, Male, Varicocele
Conditions
Keywords
Male infertility, Varicocele, Cystatin C, Endoglin
Brief summary
Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.
Detailed description
Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele
Interventions
PROCEDUREVaricocelectomy
Subinguinal varicocelectomy under general anesthesia and complete aseptic condition
Sponsors
Benha University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Infertile men * Varicocele * Poor sperm parameters
Exclusion criteria
* Men with systemic diseases * Infertile men due to other causes than varicocele
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Quality of Semen | 6 months | According to WHO 2010 guidelines regarding semen analysis * Sperm concentration (to be more than 15 million sperm per milliliter). * Sperm motility (not less than 60% progressive motility). * Sperm morphology (not less than 6% normal morphology). |
Countries
Egypt
Outcome results
None listed