Multiple Sclerosis, Progressive Multiple Sclerosis
Conditions
Brief summary
This study is a case-control study, involving persons with progressive multiple sclerosis and healthy controls. The study contains 1 descriptive and 3 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, with period and phase auditory manipulations. In the latter twp sessions, apart from outcome measures of synchronization the following will be collected as well: brain activity using EEG recordings, spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.
Interventions
The study contains 1 descriptive and 3 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, with period and phase auditory manipulations
Sponsors
National MS Center Melsbroek
Revalidatie & MS Centrum Overpelt
Hasselt University
Study design
Allocation
NA
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnosis of Multiple sclerosis \>1 year, diagnosis of progressive MS, * walking speed 0.8-1.2m/s, ability to walk for 6 minutes continuously (canes and rollators are permitted)
Exclusion criteria
* relapse 3 months prior to enrollment, * cognitive impairment impeding understanding of instructions, * beat amusia, * deafness, * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relative phase angle | week 2 | asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively) |
| Activities-specific balance confidence scale | Baseline | rating of balance confidence in performing activities of daily life |
| Modified fatigue impact scale | baseline | effect of fatigue |
| Hospital Anxiety and Depression Scale | Baseline | determine the levels of anxiety and depression |
| Dual task questionnaire | Baseline | troubles a person have when performing a dual task during daily activity |
| Perceptual tempo and rhythm judgements | week 1 | subjective indications in regards to what the participants hear in terms |
| Asynchrony | week 1 | timing difference between the tap and the beat |
| 64 channel EEG measurement | week 1 | neural correlates of entrainment |
| Resultant Vector Length | week 2 | synchronisation consistency |
| Motricity Index of dorsi flexors, knee extensors and hip flexors | baseline | Muscle weakness |
| Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts | baseline | Spasticity |
| Scale for the assessment and rating of ataxia | Baseline | ataxia |
| Dynamic gait index | Baseline | dynamic balance |
| Time up and Go test | Baseline | Balance |
| 6 minute walking test | Baseline | gait pattern and endurance |
| Brief repeatable battery of Rao | Baseline | cognitive test |
| Symbol digit mobility test | Baseline | cognitive test |
| Stroop test 0 | Baseline | cognitive test |
| MS walking scale -12 | Baseline | impact of MS on walking ability |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stride length | week 2 | distance between consecutive steps (cm) |
| Speed | week 2 | gait velocity (m/s) |
| Double Support | week 2 | time that both legs are in contact with the floor (mseconds) |
| Perceived cognitive and physical fatigue | week 2 | A visual analogue scale will be used, and participants will be asked to rate their perceived cognitive and physical fatigue levels before and after each experimental walking conditions |
| Perceived motivation | week 2 | A Likert scale will be used, and participants will be asked to rate their perceived motivation of walking after each experimental walking conditions |
| Perceived walking speed | week 2 | A Likert scale will be used, and participants will be asked to rate their perceived walking speed relative to their usual walking after each experimental walking conditions |
| 64 channel EEG measurement (only conducted in 4 PwMS and HC) | week 2 | Neural correlates of entrainment |
| Cadencce | week 2 | number of steps per minute |
Countries
Belgium
Outcome results
None listed