Multiple Sclerosis
Conditions
Brief summary
This work is embedded in the context of auditory-motor coupling, which entails the engagement of two systems; the interaction between the music (or repetitive auditory stimuli) and a walking individual (repetitive movements of footfall). In previous studies, the investigators have shown that synchronising steps to beats in music have shown to be feasible in persons with multiple sclerosis, showing increase of step frequency and reduced perceived fatigue\[1, 2\]. In this current work, The investigators expand previous findings with a pilot intervention study, to investigate if synchronisation is necessary to improve cognitive and motor functions. The proposed experiment includes 30 participants, randomised to three arms of a pilot intervention (10 participants per arm). With the intention of a further case-study analysis, the inestigators request to include 4 additional participants (2 PwMS with cognitive impairment, and 2 persons with cerebellar lesion) to only follow the intervention arm 1.
Interventions
OTHERWalking with music with synchronisation
Walking with music than one can synch to
OTHERWalking with music without synchronisation
Walking with music than one cannot synch to
OTHERwalking without music
Walking without music
Sponsors
Revalidatie & MS Centrum Overpelt
Hasselt University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* A diagnosis of MS if \>1, * no relapses \>1 month, * ability to walk for 12minutes, * ability to walk independently on a treadmill * walking speed between 0.8-1.2m/s.
Exclusion criteria
* amusia, * deafness, * cognitive impairment hindering understanding of study instructions, * pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 12- item multiple sclerosis walking scale | Baseline | The Multiple Sclerosis Walking Scale is a self-assessment scale which measures the impact of MS on walking. It consists of 12 questions concerning the limitations to walking due to MS during the past 2 weeks. Each item can be answered with 5 options, with 1 meaning no limitation and 5 extreme limitation. |
| 6 minutes walking test to calculate the distance walking Index | Baseline | impact of MS on walking |
| 12 minute walking with sensors | Baseline | gait dynamics and pattern - detrended fluctuation analysis and spatio-temporal parameters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Scale for the assessment and rating of ataxia | Baseline | Ataxia |
| Dynamic gait index | Baseline | Dynamic balance |
| Time up and Go test | Baseline | balance |
| Modified fatigue impact scale | Baseline | self-reported outcomes for fatigue |
| Barcelona music reward questionnaire | Baseline | experience of music reward |
| Paced auditory serial addition test and symbol digit modality test | Baseline | to measure cognitive functioning and cognitive fatigability |
| Activities-specific balance confidence scale | Baseline | self-reported outcome for activity and balance |
| Stroke rehabilitation motivation scale | Baseline | self-reported motivation questionnaire |
| the Brunnel Music Rating Inventory-2 | Baseline | self-reported music rating inventory |
| credibility and expectations questionnaire | week 5 | self-reporting of credibility of the intervention. |
| Pre and Post training sessions, 2x a week, 20 minutes for 4 weeks | up to week 4 | Before and after each training session * Perceived cognitive and physical fatigue rated on a visual analogue scale * Perceived motivation rated on a Likert scale |
| Hospital anxiety and depression questionnaire | Baseline | anxiety and depression |
| Motricity Index of dorsi flexors, knee extensors and hip flexors | Baseline | Muscle weakness |
| Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts | Baseline | Spasticity |
Countries
Belgium
Outcome results
None listed