Liver Transplant; Complications
Conditions
Keywords
end-stage liver disease (ESLD), frailty, prehabilitation
Brief summary
The purpose of this study is to formally identify patient and caregiver perceived needs, barriers, and facilitators to inform the development of a home-based multimodal prehabilitation program for potential LT candidates.
Detailed description
After being informed about the study and potential risks, all participants (patients and caregivers) giving written informed consent will be invited to participate in one of three research activities: interviews (n=10), nominal group technique meetings (n=64), or card-sorting and rating survey (n=40).
Interventions
BEHAVIORALPrehabilitation intervention
The investigators will identify participants' perceived important information to develop a prehabilitation intervention in this study. Prehabilitation intervention consisting of physical activities, nutrition, and stress management.
BEHAVIORALCaregiver intervention
The investigators will provide caregivers with variety of educational resources for patients experiencing ESLD.
Sponsors
University of Alabama at Birmingham
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
Liver transplant (LT) candidates are: * Adult ESLD patients (age=19-74 years) who are assigned to the LT waitlist * English-speaking * No contraindication to moderate intensity physical activities * Physician clearance for participation in moderate intensity physical activities * No history of dementia or organic brain syndrome Caregivers: * Adult (age≥ 19 years) * English-speaking * Provide direct care to LT candidates
Exclusion criteria
* Inability to communicate verbally in English * Documentation of cognitive deficits
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Liver frailty index (LFI) score | From baseline through 3 months | Change from baseline in liver frailty index score at 3 months; the higher LFI scores indicate a higher degree of frailty. LFI\<3.2: robust, LFI=3.2-4.4: prefrail, LFI\>=4.5: Frail. |
| Caregiver burden measured using Zarit Burden Interview short form (ZBI-12) | From baseline through 3 months | Change from baseline in the total ZBI-12 scores at 3 months. The total ZBI-12 score is the summation of 12 items, ranging from 0 to 48; the higher scores indicate higher burden (0-10:no to mild burden; 10-20: mild to moderate burden), and \>20: high burden. |
Countries
United States
Outcome results
None listed