Exercise, Multiple Sclerosis
Conditions
Keywords
multiple sclerosis, muscle architecture, Eccentric Exercise, Concentric Exercise
Brief summary
Selective exercise programs specific to muscle groups, with the workload to be done in line with the muscle's own structure, can enable more strength to be released with less fatigue in MS, and this increase in strength can increase balance and functional activities. to determine the effects of type training (selective exercise training), eccentric and concentric training on function, balance, fatigue and muscle architecture.
Detailed description
Recovery and enhancement of muscle function in MS is one of the main goals in physiotherapy and rehabilitation. In literature studies, it is stated that eccentric and concentric exercises are effective exercise approaches in increasing strength and reducing fatigue. However, the best exercise method is not yet clear in terms of providing better performance adaptation with less fatigue. Considering the architectural features of the lower extremity muscles, it is aimed to increase the angle of pennation with programs that include concentric strengthening of the quadriceps, gastro-soleus and gastrocnemius muscles, which are suitable muscle groups to produce large forces by design. With programs that include eccentric strengthening of the hamstring and tibialis anterior muscles that function in a wide range of motion and have high excursion ability, it is aimed to increase fiber length.
Interventions
OTHERexercise
exercise training for 8 weeks
Sponsors
Sanko University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Between the ages of 18-50, * With an Extended Disability Status Scale (EDSS) score of 4 or less, * No regular exercise habit * Able to walk on the treadmill, * No pregnancy, * Not receiving corticosteroid treatment in the last month, * Fampridine etc. in the last 1 month. not taking medication, * Patients who have not received Botox treatment in the last 6 months
Exclusion criteria
patients who do not agree to volunteer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| muscle architecture parameter 1 | Change from Baseline at 8th weeks and 12th weeks | The pennation angle were evaluated with Ultrasound |
| muscle architecture parameter 2 | Change from Baseline at 8th weeks and 12th weeks | The fiber length were evaluated with Ultrasound |
| muscle architecture parameter 3 | Change from Baseline at 8th weeks and 12th weeks | The muscle thickness were evaluated with Ultrasound |
| Muscle strength | Change from Baseline at 8th weeks and 12th weeks | low extremity muscles were evaluated with hand dynamometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| dynamic balance | Change from Baseline at 8th weeks and 12th weeks | 4 square step tests |
| Functional activities 1 | Change from Baseline at 8th weeks and 12th weeks | timed-up go test |
| walking fatigue | Change from Baseline at 8th weeks and 12th weeks | Walking Fatigue Index |
| Functional activities 3 | Change from Baseline at 8th weeks and 12th weeks | 25-feet walk test |
| Functional activities 2 | Change from Baseline at 8th weeks and 12th weeks | 2-minute walk test |
| perceived fatigue | Change from Baseline at 8th weeks and 12th weeks | Fatigue Severity Scale |
| physical fatigue | Change from Baseline at 8th weeks and 12th weeks | Modified Borg Scale before and after 6-minute walking test |
| static balance | Change from Baseline at 8th weeks and 12th weeks | Single standing tests |
Countries
Turkey (Türkiye)
Outcome results
None listed