Liver Transplant; Complications, Perioperative/Postoperative Complications
Conditions
Keywords
Age Related Outcomes, BMI related outcomes, Liver Transplantation
Brief summary
Prospectively enrolled retrospective chart review and Liver Transplant database review to determine the modifiable and nonmodifiable risk factors specifically relating to Living Donor Liver Transplants. To observe the impact of age and BMI on graft outcomes and whether they impact the intraoperative management, post-operative length of stay, and complications.
Detailed description
There has been a great deal of research into the characteristics of the donor for organ transplant, with older donors and those with more comorbidities having worse function once the organ is implanted. There has not been a great deal of research in the United States about the recipient's characteristic including age and BMI and the effects on donor organ function. With increasingly expanded criteria for organ recipients especially in the field of living donor organs the investigators plan to show the impact of older age and increased BMI on newly transplanted organs.
Interventions
PROCEDURECadaveric
Cadaveric Organ Transplant
PROCEDURELiving Donor
Living Donor Organ Transplant
Sponsors
University of Pittsburgh
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients who received a liver transplant at UPMC- Montefiore Hospital Age\> 18
Exclusion criteria
* Excludes Children (\<18 years old) as they do not receive their operation under the same protocols Lost to follow-up prior to 1 year Participation in alternate research protocol that significantly altered the care they received in the perioperative period that may make their inclusion skew results.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Graft Function 30 day | 30 day | How well does the organ function |
| Mortality | 1 year | Mortality at 1 year |
| Graft Survival 1 year | 1 year | Survival of Organ at 1 year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Complications | Up to 6 months | Complications in the postoperative period- Renal, Infectious Disease, Pulmonary, Cardiac, Transplant related, Reintubation, Reoperation |
| Perioperative Complications | 30 day | Any complications in the perioperative period |
| Vasoactive Medication | Up to 2 days | Amount and Type of Vasoactive Medication used at procedure end |
| Blood Transfusion | Up to 2 days | Amount of blood transfusion required intraoperatively |
| Length of Stay- Total and ICU | Up to 6 months | How long after surgery before patient is discharged from ICU and from Hospital |
| Duration of Intubation/Ventilation | Up to 6 months | Time from Surgery End to Extubation or no longer requiring ventilatory support |
Countries
United States
Outcome results
None listed