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Efficacy of a Microalgae Extract PhaeoSOL Combined With Natural Stimulant on Cognitive Function and Gaming Performance of Video Gamers

Efficacy of a Microalgae Extract PhaeoSOL Combined With Natural Stimulant on Cognitive Function and Gaming Performance of Video Gamers

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04851899
Acronym
PHAEOSOL-TWO
Enrollment
60
Registered
2021-04-21
Start date
2021-04-26
Completion date
2022-06-01
Last updated
2022-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Function, Video Gamers

Keywords

Fucoxanthin, Microalgae, Gaming performance, E-sports, Cognitive performance, Energy

Brief summary

Considering the important growing development of gaming in the world, this research area has developed considerably over the last few years. Even if it seems to be well admitted that video gamers showed better cognitive functions (e.g. visual selective attention, cognitive flexibility, task switching) parameters compared to non video gamers there is a constant concern for optimizing performance as for all other kind of athletes. However to our knowledge, only one randomized controlled trial have investigated the potential benefits of dietary supplementation on cognitive function and performance in video gamers. The use of microalgea as molecule of interest sources is a recent promising approach also to meet societal challenge as the maintain of biodiversity/landscape. Thus, the purpose of this study is to examine whether acute (single-dose) and chronic (1 month) supplementation of Microphyt's phaeosol ingredients (BrainPhyt) ingested with or without a natural stimulant, would affect cognitive function and gaming performance in experienced video gamers.

Interventions

DIETARY_SUPPLEMENTPhaeosol low dose

1 Phaeosol softgel of 440mg/day and 1 placebo softgel of 500mg/day (look like softgel of Phaeosol product) + 1 capsule of 440mg/day of natural stimulant Subjects were instructed to take the study supplement or placebo once daily for 1 months (±2 days). The first and the last doses will be administered at the clinical site during Visit 2 (Experiment 1) and Visit 3 (Experiment 2, respectively).

DIETARY_SUPPLEMENTPhaeosol high dose

2 Phaeosol softgels of 440mg/day + 1 capsule of 440mg/day of natural stimulant. Subjects were instructed to take the study supplement or placebo once daily for 1 months (±2 days). The first and the last doses will be administered at the clinical site during Visit 2 (Experiment 1) and Visit 3 (Experiment 2, respectively).

DIETARY_SUPPLEMENTPlacebo

2 placebo softgels of 440mg/day (look like softgel of Phaeosol product) + 1 capsule of 500mg/day containing Microcellulose (look like capsule of natural stimulant). Subjects were instructed to take the study supplement or placebo once daily for 1 months (±2 days). The first and the last doses will be administered at the clinical site during Visit 2 (Experiment 1) and Visit 3 (Experiment 2, respectively).

Sponsors

Texas A&M University
CollaboratorOTHER
Microphyt
Lead SponsorINDUSTRY

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

1. Healthy men and women; 2. Between 18 and 40 years; 3. Self-reported history of playing video games for 5 or more hours per week for 6 months prior to screening; 4. BMI between 18 and 34.9 Kg/m2 ; 5. Subjects agreed to supply their own operator-oriented action or strategy video game that they had played at least 21 times over the last 3 months; 6. No recent ingestion (\<2weeks) of dietary supplement that affect cognitive function; 7. Be able to give written informed consent and to consume the investigational product daily for the duration of the study; 8. Is free-living (living in a private home, alone or with family, and able to maintain their health and hygiene without assistance) 9. Willing to maintain consistent sleep duration the evening before study visits. 10. Are agreed to continue their patterned use of the game between study visits

Exclusion criteria

1. refrain from caffeine and alcohol for 12 hours prior to each study visits; 2. consume dietary supplements that may affect cognition and/or with a stimulant effect (e.g. guarana, cocoa, ginseng, bacopa, Gingko biloba, guayusa, yerba mate, energy drinks, other products containing fucoxanthin) at least 7 days before Visit 2 ; 3. are women who are pregnant, breastfeeding, or wish to become pregnant during the study; 4. have an untreated psychotic or major depressive disorder or any history of cognitive deficit; 5. have an uncontrolled hypertension/diabetes/thyroid/heart disease disease, cancer etc.); 6. have a significant neurological disease; 7. have planned major changes in lifestyle (i.e. diet, dieting, exercise level, travelling) during the duration of the study; 8. have a history within previous 12 months of alcohol or substance abuse; 9. have known allergy to any of the ingredients in the supplement product 10. are not willing to supply their own gaming system and/or game

Design outcomes

Primary

MeasureTime frameDescription
Reaction timeFrom week 0 to week 4Change in reaction time - Light tracking test
General attentionFrom week 0 to week 4Change in general attention score - Go no go task test
Sustained attentionFrom week 0 to week 4Change in sustained attention score - Psychomotor vigilance task test
Attention shiftingFrom week 0 to week 4Change in attention shifting score - Berg-Washington card sorting task test

Secondary

MeasureTime frameDescription
Gaming performanceFrom week 0 to week 4Change in gaming performance score from 0 to 100 - Higher scores mean a better outcome
Global fatigueFrom week 0 to week 4Change in global fatigue score - Visual analogic scale from 0 to 100 - higher scores mean a worse outcome
Mood stateFrom week 0 to week 4Change in Mood state questionnaire score from 0 to 100 - Higher scores mean a better outcome - Profil of Mood state questionnaire
Sleep qualityFrom week 0 to week 4Change in sleep quality questionnaire score from 0 to 100 - Higher scores mean a better outcome
Eyes irritabilityFrom week 0 to week 4Change in eyes irritability score -Visual analogic scale from 0 to 100 - Higher scores mean a worse outcome

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026