Postoperative VEGF and Recurrence After Colon Cancer Surgery

Postoperative Serum VEGF Concentration as an Independent Prognostic Factor for Recurrence After Curative Colon Cancer Surgery. Multicentric Study.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04851054

Enrollment

280

Registered

2021-04-20

Start date

2017-01-01

Completion date

2021-12-31

Last updated

2021-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angiogenesis, Colon Cancer, Recurrence, Surgery, VEGF Overexpression

Keywords

VEGF, Colon Cancer, Surgery, Recurrence

Brief summary

The purpose of this trial is to study the relationship between the angiogenic response to surgical aggression, determined through the serum levels of vascular endothelial growth factor (VEGF) on postoperative day four, and the tumor recurrence in patients with colon cancer operated with a curative intention.

Detailed description

DESIGN: Prospective multicentric study. PARTICIPATION: Colorectal Surgery Units of Hospital del Mar, Barcelona; Hospital Universitari Joan XXIII, Tarragona; Hospital Universitari La Fe, Valencia; Hospital Clínico San Carlos, Madrid; Hospital General de Granollers, Granollers; Hospital Germans Trias i Pujol, Badalona; Athalaia, Xarxa Assistencial Universitària de Manresa, Manresa STUDY SUBJECTS: 280 consecutive patients with non-metastatic colon cancer in whom a curative intent resection is performed. DETERMINATIONS: Determination of the proangiogenic cytokine VEGF in serum on the postoperative day four to assess its relationship with oncological results on long-term follow-up.

Interventions

PROCEDURESurgery for colon cancer with intention to cure

Surgery by open or laparoscopic approach

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with colon cancer admitted to the Colorectal Surgery Unit of the centers participating in the study, * Patients who will undergo elective surgical resection with potentially curative intention

Exclusion criteria

* Patients with metastatic disease * Patients with synchronous colon neoplasia or in the previous five years * Patients undergoing emergency surgery * Patients who do not sign the informed consent.

Design outcomes

Primary

Measure	Time frame	Description
VEGF in serum on postop day 4	Postoperative day 4	A 10cc sample of peripheral blood will be drawn on postoperative day 4

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026