MRI-guided Lateral Lymph Node Dissection in Rectal Cancer

Conditions

Rectal Cancer

Keywords

Lateral lymph node, Surgery, Magnetic resonance imaging, oncological outcome

Brief summary

To investigate the oncological outcome of lateral lymph node dissection in low rectal cancer based on MRI

Detailed description

Our study design is a multicenter, prospective, registry study. We would enroll 268 patients with lower rectal cancer whose preoperative MRI showed laterally lymph node diameter ≥ 5mm. The postoperative adjuvant chemoradiotherapy is determined by the pathological results. For patients of stage II and patients of stage III with unfavorable histologic features, six months of adjuvant chemotherapy of fluorouracil-based regimen with radiotherapy of 45.0 \ 50.5 Gy are recommended. The postoperative examination should be performed every three months in the first two years and every six months in the following three years. Our study is expected to last five years, of which two years for recruiting patients, three years for follow-up.

Fei Huang, Ran Wei, Sicheng Zhou, Shiwen Mei, Tixian Xiao et al. (8 authors)

Discover Oncology2024-11-043 citations

10.1007/s12672-024-01500-4

Neoadjuvant chemotherapy with FOLFOXIRI plus lateral lymph nodes dissection for the treatment of resectable rectal cancer with lateral lymph node metastasis: A single-arm, investigator-initiated, phase II trial.

Yongkun Sun, Yujuan Jiang, Haitao Zhou, Wei Pei, Zheng Jiang et al. (19 authors)

Journal of Clinical Oncology2024-06-01

10.1200/jco.2024.42.16_suppl.3533

Feasibility and safety of lateral pelvic lymph node dissection for elderly patients with middle-low rectal cancer: results of a large multicenter lateral node collaborative group study in China.

Zhou S, Mei S, Feng B, Yang Y, Wang X, Wang Q, Liu Q.

2022-12-14

10.1007/s10151-022-02746-2

Effective dissecting range and prognostic significance of lateral pelvic lymph node dissection for middle-low rectal cancer patients with lateral pelvic lymph node metastasis: Results of a large multicenter lateral node collaborative group in China

Sicheng Zhou, Jianqiang Tang, Jianwei Liang, Zheng Lou, Wei Fu et al. (9 authors)

Frontiers in Oncology2022-08-128 citations

10.3389/fonc.2022.916285

Interventions

PROCEDURETME+Lateral lymph node dissection.

TME and lateral lymph node dissection is performed in rectal cancer patients with lateral lymph node short diameter ≥ 5 mm.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

No

Inclusion criteria

1. Age between 18-75 years old 2. Pathologically confirmed as rectal adenocarcinoma 3. The tumor is located in the middle or lower rectum 4. Preoperative MRI assessment is T2-4 N+M0 5. Lateral lymph node short diameter ≥ 5 mm (MRI) 6. Signed informed consent

Exclusion criteria

1. Previous history of malignant colorectal tumors 2. Multiple abdominal or pelvic surgeries were performed 3. Complicated with bowel obstruction, perforation or bleeding 4. Patients undergoing palliative surgery 5. Patients with severe liver and kidney dysfunction, cardiopulmonary dysfunction, blood coagulation dysfunction, or combined with serious underlying diseases that cannot tolerate surgery 6. Have a history of severe mental illness 7. Pregnant or breastfeeding women （8) Patients previously treated with iliac artery surgery (or its branches) (9) R0 resection cannot complete (10) ASA grade ≥ IV

Design outcomes

Primary

Measure	Time frame	Description
Overall survival rate	3-year	The proportion of patients survived after 3 years of surgery
Pathological positive rate	3-year.	The proportion of patients with positive lateral lymph node which was confirmed pathologically.
Local recurrence rate	3-year	The proportion of patients with local recurrence after 3 years of surgery
Disease free survival	3-year	The proportion of patients with no disease recurrence and metastasis after 3 years of surgery.

Secondary

Measure	Time frame	Description
Duration of the surgery	1 day	The duration of time between the start and the end of the surgery.
Postoperative complications	30 days	Complications occurring within 30 days after surgery, mainly urinary and sexual functions.
Early morbidity rate	30 days	The early morbidity rate is defined as the event observed during operation and within 30 days after surgery

Countries

China

Contacts

Primary ContactQian Liu, M.D

fcwpumch@163.com01087787110

Outcome results

None listed