Covid19, Critical Illness, Muscle Atrophy, Muscle Strength
Conditions
Brief summary
Muscle loss (ultrasound quadricep muscle) and muscle strength (handgrip and knee extension strength) will be compared between COVID-19 and non COVID-19 critically ill patients.
Detailed description
Given the heightened inflammatory status among COVID-19 critically ill patients, we hypothesized that the rate of skeletal muscle loss is accelerated in this population, and this loss is even more pronounce than the general critically ill patients. We further hypothesized that the increased muscle loss will lead to worse functional outcome (lower muscle strength) in COVID-19 critically ill patients compared with age- and sex-matched non-COVID-19 critically ill patients, as it has been shown that quadriceps thickness is strongly correlated with functional status at ICU discharge. Furthermore, a recent systematic review and meta-analysis in survivors of coronavirus (severe acute respiratory syndrome, SARS or Middle-east respiratory syndrome, MERS, or COVID-19) also demonstrated reduced exercise capacity and quality of life at 6 months after hospitalization or ICU admission
Interventions
OTHERNo Intervention
This is an observational study and involved no intervention
Sponsors
University of Malaya
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* ≥ 18 years old * Admitted into the ICU due to COVID-19
Exclusion criteria
* Likely to transfer out from the ICU in 24 hours from screening * Likely to die in the next 7 days * Bedbound prior to hospital admission or bedbound in the hospital for \>10 days
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rectus Femoris Thickness | Change in Rectus Femoris Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission) | Change in Rectus Femoris Thickness |
| Rectus Femoris Cross-sectional Area | Change in Rectus Femoris Cross-sectional Area at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission) | Change in Rectus Femoris Cross-sectional Area |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Forearm Muscle Thickness | Change in Forearm Muscle Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission) | Change in Forearm Muscle Thickness |
| Handgrip Strength | Before Hospital Discharge | BIlateral Handgrip Strength |
| Knee Extension Strength | Before Hospital Discharge | BIlateral Knee Extension Strength |
Countries
Malaysia
Outcome results
None listed