Chronic Obstructive Pulmonary Disease Severe
Conditions
Brief summary
Patients with chronic obstructive pulmonary disease (COPD) can eventually progress to respiratory failure, where they cannot adequately exchange oxygen and carbon dioxide, leading to worsening breathlessness, frequent hospitalisations and death. Non-invasive ventilation (NIV) is a ventilator therapy that is used in COPD patients who suffer from respiratory failure. Studies have demonstrated that using NIV at night regularly can result in improved clinical outcomes. Adherence to this therapy is variable, however. This can be due to poor synchrony between the device and the lungs. A novel ventilator has been designed that delivers NIV but is also incorporated with technology to assess for aberrations in respiratory physiology and correct them, breath-by-breath. The investigators aim to assess the efficacy, safety and tolerability of this novel ventilator. The primary research question is whether the novel ventilator can improve adherence to therapy, when compared with the usual ventilator. Patients with COPD who use ventilation at home will be screened for inclusion in the study. Participation will involve a screening visit, and a further two visits to the Lane Fox Respiratory Unit. The first will require a two-night admission and the second a single-night admission. They will undergo detailed assessment of their daytime and overnight respiratory and sleep physiology during these admissions. These visits will be separated by a six-week period during which they will be asked to use the novel ventilator at home. Patients will be recruited into a sub-study to evaluate the performance of the ventilator in a daytime physiological assessment. This will involve detailed invasive physiological assessment of expiratory flow limitation and how the machine is able to adjust settings to optimise respiratory support.
Interventions
DEVICEAuto-titrating non-invasive ventilation
A non-invasive ventilator designed to auto-adjust the expiratory positive airway pressure according to expiratory flow limitation, measured using the forced oscillation technique.
Sponsors
Guy's and St Thomas' NHS Foundation Trust
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
12 weeks sequential (pre/post) study. Participants will receive usual NIV treatment for 6 weeks followed by novel ventilator for 6 weeks. There will be a randomised crossover element for one night at the midpoint of the study to assess sleep parameters on the two ventilation modalities.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Patient Inclusion Criteria: * Age ≥ 18 years * BMI \<30 kg/m¬2 * Confirmed diagnosis of COPD * Currently using domiciliary NIV with average reported compliance of at least 3hours * Ability to provide informed consent * Medical stability confirmed by recruiting physician * Free of exacerbations for at least 2 weeks prior to enrolment * Presence of expiratory flow limitation on forced oscillation technique criteria
Exclusion criteria
* Current acute illness as determined by recruiting physician e.g. upper respiratory tract infection * Presence of major medical comorbidity, e.g. severe heart failure (LVEF \<30%), active malignancy, end-stage renal failure (CKD 4), and neuromuscular disease * Subjects who have had surgery of the upper airway, nose, sinus, or middle ear within the previous 90 days. * Psychosocial factors that would prevent compliance with study protocol Healthy participant inclusion criteria: * Age ≥ 18 years * No expiratory flow limitation on forced oscillation testing * No acute illness on study day * Ability to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adherence to ventilation therapy | 6 weeks | Number of hours spent on nocturnal ventilation therapy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean nocturnal transcutaneous carbon dioxide level | 1 night during single night admission | Mean nocturnal transcutaneous carbon dioxide level measured on single night admission |
| Maximal nocturnal transcutaneous carbon dioxide level | 1 night during single night admission | Maximal nocturnal transcutaneous carbon dioxide level measured on single night admission |
| Sleep parameters | 1 night during single night admission | Sleep efficiency, measured by polysomnography |
| Inspiratory capacity | 6 weeks | Inspiratory capacity following 6 weeks of each NIV device |
| Health-related quality of life | 6 weeks | Measured using COPD Assessment Test |
| Daytime physical activity | 2 weeks | Measured using wrist actigraphs during the final 2 weeks of each 6 week arm |
Countries
United Kingdom
Contacts
PRINCIPAL_INVESTIGATORNeeraj Shah
Guy's and St Thomas' NHS Foundation Trust
STUDY_CHAIRNicholas Hart
Guy's and St Thomas' NHS Foundation Trust
STUDY_DIRECTORPatrick Murphy
Guy's and St Thomas' NHS Foundation Trust
Outcome results
None listed