Exercise-Induced Hyperinsulinism, Glucose, High Blood
Conditions
Brief summary
It is well established that a bout of 50 min of continuous moderate intensity exercise, improves insulin sensitivity up to 48 hours after the bout. However, it is less well known, what is the exercise type more efficient to buffer the elevations in blood glucose elicited by carbohydrate ingestion. The purpose of this study is to elucidate if intervalic exercise is superior to continous on improving postprandial glycemic control.
Detailed description
Carbohydrate oxidation, glucose and insulin blood concentrations, isotopically measured rate of appearance of endogenous and exogenous glucose will be measured in 4 ocassions. Participants will undergo in a cross-over randomized fashion the following trials: 1. Exercise pedalling during 50 min at 60% of their VO2max followed by an oral glucose tolerance test (OGTT). 2. Exercise pedalling during 50 min in a hot environment (33ºC) at 60% of their VO2max followed by an oral glucose tolerance test (OGTT). 3. Exercise pedalling during 50 min using intervalic bouts averaging 60% of VO2max followed by an oral glucose tolerance test (OGTT). 4. No exercise, followed by an oral glucose tolerance test (OGTT).
Interventions
BEHAVIORALTYPE OF EXERCISE (OR REST)
continous exercise in normal temperature, continous exercise in hot environment, intervallic exercise in normal temperature.
Sponsors
University of Castilla-La Mancha
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Intervention model description
Study composed of 4 trials, full-crossover, administered in a randomized order with the inclusion of a control trial.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Participant must be capable and willing to provide consent, understand, instructions and protocols. * Minimal fitness level to be able to complete 50 min of continous exercise at a moderate intensity.
Exclusion criteria
* Smokers * Pregnancy * Any non-controlled medical condition which could influence results or could be worsened by exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood glucose concentration | 16 weeks | Incremental area under the curve during the 120 min of the oral glucose tolerance test |
| Blood insulin concentration | 16 weeks | Incremental area under the curve during the 120 min of the oral glucose tolerance test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Carbohydrate oxidation | 16 weeks | Measured using indirect calorimetry |
| Turnover rate of endogenous and exogenous glucose | 16 weeks | Measured using isotopic tracers. |
Countries
Spain
Outcome results
None listed