Brain Damage
Conditions
Keywords
Brain injury, Transcranial Doppler, Quantitative Pupillometry,, neurological prognosis, modified Rankin Score (mRS), Glasgow Outcome Scale Extended (GOS-E)
Brief summary
Transcranial Doppler is performed daily in Intensive Care Unit in brain damaged patients. For a few years now, the measurement of the photomotor reflex by quantitative Pupillometry has been routinely performed in Intensive Care Units. The objective of this work is to see if Transcranial Doppler recorded parameters and Pupillary parameters are correlated to the neurological prognosis evaluated at 9 months by the Modified Rankin Score (mRS) and the Glasgow Outcome Scale Extended (GOS-E).
Interventions
DEVICETranscranial Doppler
This device measures Mean Systolic Velocity (VMS), Tele-Diastolic Velocity (TDV) and Pulsatility Index (PI),
DEVICEPupillometry.
This device measures the photomotor reflex (basic pupil diameter, percentage of variation, latent and slope of the standard photomotor reflex)
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All brain damaged patients (stroke or head trauma) * Admitted to Intensive Care Unit since December 1, 2020
Exclusion criteria
* Refusal by the patient or his/her legal representative. * Benefiting from legal protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Modified Rankin Score (mRS) (0-5) | Year: 1 | Modified Rankin Score (mRS) measures the degree of disability following a stroke in a patient (level 0 for patients with no symptoms to level 5 for patients with major disability and total dependency).. |
| Glasgow Outcome Scale Extended (GOS-E) (1-8) | Year: 1 | Glasgow Outcome Scale Extended (GOS-E) measure the impact of brain injured (minimum at 1 (Dead) and maximum at 8 (Upper Good Recovery). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tissue Partial Oxygen Pressure (PtiO2) | At inclusion | Collect on medical file. |
| Bispectral Index (BIS) | At inclusion | Collect on medical file. BIS is a reflection of the depth of hypnosis |
| Basic pupil diameter | At inclusion | Measured by Pupillometry right and left |
| Mean Systolic Velocity (VMS) | At inclusion | Measured by Transcranial Doppler right and left. |
| Intra-Cranial Pressure (ICP) | At inclusion | Collect on medical file. |
| Pulsatility Index (PI) | At inclusion | Measured by Transcranial Doppler right and left. |
| Percentage of variation of the pupil diameter | At inclusion | Measured by Pupillometry right and left |
| Richmond Agitation-Sedation Scale (RASS) | At inclusion | Richmond Agitation-Sedation Scale (RASS) is a symmetrical rating, with positive values for agitation and negative values for the level of consciousness around a point 0 corresponding to a calm and awake patient. Collect on medical file. |
| Heart rate | At inclusion | Collect on medical file. |
| Blood pressure | At inclusion | Collect on medical file. |
| Natremia (mmol/l) | At inclusion | Collect on medical file. |
| Glycemia (mmol/l) | At inclusion | Collect on medical file. |
| Tele-Diastolic Velocity (TDV) | At inclusion | Measured by Transcranial Doppler right and left. |
| Latent and slope of the standard photomotor reflex | At inclusion | Measured by Pupillometry right and left |
Countries
France
Outcome results
None listed