Laparoscopic Cholecystectomy, Postoperative Analgesia, Erector Spinae Plane Block, Quadratus Lumborum Block
Conditions
Brief summary
The aim of this study is to compare between the efficacy of ultrasound guided erector spinae plane block and ultrasound guided quadratus lumborum block in managing acute postoperative pain in patients undergoing laparoscopic cholecystectomy.
Interventions
OTHERControl group
patients will receive general anesthesia only.
PROCEDUREErector spinae plane block group
patients will receive general anesthesia and bilateral ultrasound guided erector spinae plane block (20ml Bupivacaine 0.25%)
PROCEDUREQuadratus lumborum block group
patients will receive general anesthesia and bilateral ultrasound guided quadratus lumborum block (20 ml Bupivacaine 0.25%)
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Patients and medical personnel collecting data and conducting follow-up will be blinded to the group of the patient. All blocks will be performed by one anesthesiologist who will not participate in data collection or analysis.
Eligibility
Sex/Gender
ALL
Age
21 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* aged 21-65 years * both genders * American Society of Anesthesiology (ASA) class I-II * Undergoing elective laparoscopic cholecystectomy
Exclusion criteria
* Patient refusal. * Coagulopathy. * History of allergy to local anaesthetic. * History of liver or renal pathology affecting drug elimination * Mental dysfunction or cognitive disorders. * Use of medication such as gabapentin-pregabalin that could affect pain perception. * Body Mass Index \> 40 kg/m2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The degree of postoperative pain in the first 24 hours post-operative | first 24 hours post-operative | Postoperative pain will be assessed by the numerical rating scale (NRS); 0 no pain while 10 is the maximum pain) after discharge to the ward ,and at 6, 12, 18, 24 hours. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to first analgesic requirement | first 24 hours post-operative | Intravenous morphine 2 mg will be given when the numerical rating scale (NRS) equal or above 4 |
| Total dose of intraoperative consumption of fentanyl | intraoperative | Fentanyl 0.5 μg/kg will be given if there was increase in heart rate or mean arterial blood pressure more than 20% (after exclusion of other causes than pain). |
| Total dose of rescue analgesia in the first 24hr postoperative | first 24 hours post-operative | Total morphine consumption 24 hours after surgery will be recorded. Intravenous morphine 2 mg will be given when the numerical rating scale (NRS) equal or above 4 |
Contacts
Primary ContactMai E Hamada, MBBCH
Outcome results
None listed